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Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

Author

Listed:
  • Amit K. Subudhi

    (King Abdullah University of Science and Technology (KAUST))

  • Aidan J. O’Donnell

    (University of Edinburgh)

  • Abhinay Ramaprasad

    (King Abdullah University of Science and Technology (KAUST))

  • Hussein M. Abkallo

    (Nagasaki University)

  • Abhinav Kaushik

    (King Abdullah University of Science and Technology (KAUST))

  • Hifzur R. Ansari

    (King Abdullah University of Science and Technology (KAUST))

  • Alyaa M. Abdel-Haleem

    (King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology (KAUST))

  • Fathia Rached

    (King Abdullah University of Science and Technology (KAUST))

  • Osamu Kaneko

    (Nagasaki University)

  • Richard Culleton

    (Nagasaki University
    Ehime University)

  • Sarah E. Reece

    (University of Edinburgh)

  • Arnab Pain

    (King Abdullah University of Science and Technology (KAUST)
    Hokkaido University
    University of Oxford)

Abstract

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches utilizing rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit daily rhythms in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 6% of Plasmodium falciparum genes show 24 h rhythms in expression under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a 24 h transcriptional rhythm and disrupting it in rodent malaria parasites shortens the IDC by 2-3 h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathways, are affected by loss of coordination with host rhythms and by disruption of SR10. Our results reveal malaria parasites are at least partly responsible for scheduling the IDC and coordinating their development with host daily rhythms.

Suggested Citation

  • Amit K. Subudhi & Aidan J. O’Donnell & Abhinay Ramaprasad & Hussein M. Abkallo & Abhinav Kaushik & Hifzur R. Ansari & Alyaa M. Abdel-Haleem & Fathia Rached & Osamu Kaneko & Richard Culleton & Sarah E., 2020. "Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16593-y
    DOI: 10.1038/s41467-020-16593-y
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    Cited by:

    1. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Michael F. Duffy & Gerry Q. Tonkin-Hill & Leily Trianty & Rintis Noviyanti & Hanh H. T. Nguyen & Janavi S. Rambhatla & Malcolm J. McConville & Stephen J. Rogerson & Graham V. Brown & Ric N. Price & Ni, 2022. "Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass," Nature Communications, Nature, vol. 13(1), pages 1-3, December.

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