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Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula

Author

Listed:
  • Paola Roggero

    (Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (IRCCS)
    Department of Clinical Sciences and Community Health, University of Milan)

  • Nadia Liotto

    (Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (IRCCS))

  • Chiara Pozzi

    (Humanitas Clinical and Research Center—IRCCS)

  • Daniele Braga

    (Humanitas Clinical and Research Center—IRCCS)

  • Jacopo Troisi

    (Theoreo Srl
    European Biomedical Research Institute of Salerno (EBRIS)
    Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno)

  • Camilla Menis

    (Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (IRCCS)
    Department of Clinical Sciences and Community Health, University of Milan)

  • Maria Lorella Giannì

    (Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (IRCCS)
    Department of Clinical Sciences and Community Health, University of Milan)

  • Roberto Berni Canani

    (Department of Translational Medical Science, University Federico II
    ImmunoNutritionLab at CEINGE-Biotecnologie Avanzate s.c.ar.l., University Federico II
    European Laboratory for the Investigation of Food-Induced Diseases, University Federico II
    Task Force on Microbiome Studies, University Federico II)

  • Lorella Paparo

    (Department of Translational Medical Science, University Federico II
    ImmunoNutritionLab at CEINGE-Biotecnologie Avanzate s.c.ar.l., University Federico II)

  • Rita Nocerino

    (Department of Translational Medical Science, University Federico II
    ImmunoNutritionLab at CEINGE-Biotecnologie Avanzate s.c.ar.l., University Federico II)

  • Andrea Budelli

    (School of Engineering, Niccoló Cusano University)

  • Fabio Mosca

    (Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (IRCCS)
    Department of Clinical Sciences and Community Health, University of Milan)

  • Maria Rescigno

    (Humanitas Clinical and Research Center—IRCCS
    Humanitas University Department of Biomedical Sciences, Via Rita Levi Montalcini 4)

Abstract

Mother’s milk is the best choice for infants nutrition, however when it is not available or insufficient to satisfy the needs of the infant, formula is proposed as an effective substitute. Here, we report the results of a randomized controlled clinical trial (NCT03637894) designed to evaluate the effects of two different dietary regimens (standard formula and Lactobacillus paracasei CBA L74-fermented formula) versus breastfeeding (reference group) on immune defense mechanisms (primary endpoint: secretory IgA, antimicrobial peptides), the microbiota and its metabolome (secondary outcomes), in healthy full term infants according to the type of delivery (n = 13/group). We show that the fermented formula, safe and well tolerated, induces an increase in secretory IgA (but not in antimicrobial peptides) and reduces the diversity of the microbiota, similarly, but not as much as, breastmilk. Metabolome analysis allowed us to distinguish subjects based on their dietary regimen and mode of delivery. Together, these results suggest that a fermented formula favors the maturation of the immune system, microbiota and metabolome.

Suggested Citation

  • Paola Roggero & Nadia Liotto & Chiara Pozzi & Daniele Braga & Jacopo Troisi & Camilla Menis & Maria Lorella Giannì & Roberto Berni Canani & Lorella Paparo & Rita Nocerino & Andrea Budelli & Fabio Mosc, 2020. "Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16582-1
    DOI: 10.1038/s41467-020-16582-1
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