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Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy

Author

Listed:
  • Kuan Hu

    (National Institutes for Quantum and Radiological Science and Technology)

  • Lin Xie

    (National Institutes for Quantum and Radiological Science and Technology)

  • Yiding Zhang

    (National Institutes for Quantum and Radiological Science and Technology)

  • Masayuki Hanyu

    (National Institutes for Quantum and Radiological Science and Technology)

  • Zhimin Yang

    (National Institutes for Quantum and Radiological Science and Technology
    The First Affiliated Hospital of Jinan University)

  • Kotaro Nagatsu

    (National Institutes for Quantum and Radiological Science and Technology)

  • Hisashi Suzuki

    (National Institutes for Quantum and Radiological Science and Technology)

  • Jiang Ouyang

    (Harvard Medical School)

  • Xiaoyuan Ji

    (Harvard Medical School)

  • Junjie Wei

    (The First Affiliated Hospital of Jinan University)

  • Hao Xu

    (The First Affiliated Hospital of Jinan University)

  • Omid C. Farokhzad

    (Harvard Medical School)

  • Steven H. Liang

    (Harvard Medical School)

  • Lu Wang

    (The First Affiliated Hospital of Jinan University
    Harvard Medical School)

  • Wei Tao

    (Harvard Medical School)

  • Ming-Rong Zhang

    (National Institutes for Quantum and Radiological Science and Technology)

Abstract

The use of photothermal agents (PTAs) in cancer photothermal therapy (PTT) has shown promising results in clinical studies. The rapid degradation of PTAs may address safety concerns but usually limits the photothermal stability required for efficacious treatment. Conversely, PTAs with high photothermal stability usually degrade slowly. The solutions that address the balance between the high photothermal stability and rapid degradation of PTAs are rare. Here, we report that the inherent Cu2+-capturing ability of black phosphorus (BP) can accelerate the degradation of BP, while also enhancing photothermal stability. The incorporation of Cu2+ into BP@Cu nanostructures further enables chemodynamic therapy (CDT)-enhanced PTT. Moreover, by employing 64Cu2+, positron emission tomography (PET) imaging can be achieved for in vivo real-time and quantitative tracking. Therefore, our study not only introduces an “ideal” PTA that bypasses the limitations of PTAs, but also provides the proof-of-concept application of BP-based materials in PET-guided, CDT-enhanced combination cancer therapy.

Suggested Citation

  • Kuan Hu & Lin Xie & Yiding Zhang & Masayuki Hanyu & Zhimin Yang & Kotaro Nagatsu & Hisashi Suzuki & Jiang Ouyang & Xiaoyuan Ji & Junjie Wei & Hao Xu & Omid C. Farokhzad & Steven H. Liang & Lu Wang & W, 2020. "Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16513-0
    DOI: 10.1038/s41467-020-16513-0
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    Cited by:

    1. Zhaoqing Shi & Miaomiao Luo & Qili Huang & Chendi Ding & Wenyan Wang & Yinglong Wu & Jingjing Luo & Chuchu Lin & Ting Chen & Xiaowei Zeng & Lin Mei & Yanli Zhao & Hongzhong Chen, 2023. "NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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