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Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Author

Listed:
  • Haruka Toda

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Miriam Diaz-Varela

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Joan Segui-Barber

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Wanlapa Roobsoong

    (Mahidol University)

  • Barbara Baro

    (Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
    ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Susana Garcia-Silva

    (Spanish National Cancer Research Center (CNIO))

  • Alicia Galiano

    (Universitat de València)

  • Melisa Gualdrón-López

    (Germans Trias i Pujol Health Science Research Institute (IGTP))

  • Anne C. G. Almeida

    (Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
    Universidade do Estado do Amazonas (UEA))

  • Marcelo A. M. Brito

    (Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
    Universidade do Estado do Amazonas (UEA))

  • Gisely Cardoso Melo

    (Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
    Universidade do Estado do Amazonas (UEA))

  • Iris Aparici-Herraiz

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Carlos Castro-Cavadía

    (Universidad de Antioquia)

  • Wuelton Marcelo Monteiro

    (Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
    Universidade do Estado do Amazonas (UEA))

  • Eva Borràs

    (Barcelona Institute of Science and Technology (BIST)
    Universitat Pompeu Fabra (UPF))

  • Eduard Sabidó

    (Barcelona Institute of Science and Technology (BIST)
    Universitat Pompeu Fabra (UPF))

  • Igor C. Almeida

    (University of Texas El Paso)

  • Jakub Chojnacki

    (AIDS Research Institute IrsiCaixa)

  • Javier Martinez-Picado

    (Germans Trias i Pujol Health Science Research Institute (IGTP)
    AIDS Research Institute IrsiCaixa
    University of Vic-Central University of Catalonia
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • Maria Calvo

    (Universitat de Barcelona)

  • Pilar Armengol

    (Germans Trias i Pujol Health Science Research Institute (IGTP))

  • Jaime Carmona-Fonseca

    (Universidad de Antioquia)

  • Maria Fernanda Yasnot

    (Universidad de Córdoba)

  • Ricardo Lauzurica

    (Germans Trias i Pujol University Hospital)

  • Antonio Marcilla

    (Universitat de València)

  • Hector Peinado

    (Spanish National Cancer Research Center (CNIO))

  • Mary R. Galinski

    (Emory University)

  • Marcus V. G. Lacerda

    (Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)
    Instituto Leônidas & Maria Deane (ILMD), Fiocruz)

  • Jetsumon Sattabongkot

    (Mahidol University)

  • Carmen Fernandez-Becerra

    (ISGlobal, Hospital Clínic - Universitat de Barcelona
    Germans Trias i Pujol Health Science Research Institute (IGTP))

  • Hernando A. Portillo

    (ISGlobal, Hospital Clínic - Universitat de Barcelona
    Germans Trias i Pujol Health Science Research Institute (IGTP)
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

Abstract

Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.

Suggested Citation

  • Haruka Toda & Miriam Diaz-Varela & Joan Segui-Barber & Wanlapa Roobsoong & Barbara Baro & Susana Garcia-Silva & Alicia Galiano & Melisa Gualdrón-López & Anne C. G. Almeida & Marcelo A. M. Brito & Gise, 2020. "Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16337-y
    DOI: 10.1038/s41467-020-16337-y
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