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Large-scale electron microscopy database for human type 1 diabetes

Author

Listed:
  • Pascal Boer

    (University of Groningen, University Medical Center Groningen)

  • Nicole M. Pirozzi

    (University of Groningen, University Medical Center Groningen)

  • Anouk H. G. Wolters

    (University of Groningen, University Medical Center Groningen)

  • Jeroen Kuipers

    (University of Groningen, University Medical Center Groningen)

  • Irina Kusmartseva

    (University of Florida Diabetes Institute)

  • Mark A. Atkinson

    (University of Florida Diabetes Institute
    University of Florida)

  • Martha Campbell-Thompson

    (University of Florida Diabetes Institute)

  • Ben N. G. Giepmans

    (University of Groningen, University Medical Center Groningen)

Abstract

Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images (‘nanotomy’) of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of ‘intermediate cells’ containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.

Suggested Citation

  • Pascal Boer & Nicole M. Pirozzi & Anouk H. G. Wolters & Jeroen Kuipers & Irina Kusmartseva & Mark A. Atkinson & Martha Campbell-Thompson & Ben N. G. Giepmans, 2020. "Large-scale electron microscopy database for human type 1 diabetes," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16287-5
    DOI: 10.1038/s41467-020-16287-5
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    Cited by:

    1. Lihua Chen & Nannan Wang & Tongran Zhang & Feng Zhang & Wei Zhang & Hao Meng & Jingyi Chen & Zhiying Liao & Xiaopeng Xu & Zhuo Ma & Tao Xu & Huisheng Liu, 2024. "Directed differentiation of pancreatic δ cells from human pluripotent stem cells," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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