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Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Author

Listed:
  • Wei Zhang

    (Harvard Medical School)

  • Tianjiao Ji

    (Harvard Medical School)

  • Yang Li

    (Harvard Medical School)

  • Yueqin Zheng

    (Harvard Medical School)

  • Manisha Mehta

    (Harvard Medical School)

  • Chao Zhao

    (Harvard Medical School)

  • Andong Liu

    (Harvard Medical School)

  • Daniel S. Kohane

    (Harvard Medical School)

Abstract

An on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable. Here, we design and synthesize a macromolecular prodrug (P407-CM-T) in which the local anesthetic tetracaine (T) is attached to the polymer poloxamer 407 (P407) via a photo-cleavable coumarin linkage (CM). P407-CM-T solution is an injectable liquid at room temperature and gels near body temperature. The macromolecular prodrug has no anesthetic effect itself unless irradiated with a low-power blue light emitting diode (LED), resulting in local anesthesia. By adjusting the intensity and duration of irradiation, the anesthetic effect can be modulated. Local anesthesia can be repeatedly triggered.

Suggested Citation

  • Wei Zhang & Tianjiao Ji & Yang Li & Yueqin Zheng & Manisha Mehta & Chao Zhao & Andong Liu & Daniel S. Kohane, 2020. "Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16177-w
    DOI: 10.1038/s41467-020-16177-w
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