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Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

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Listed:
  • Fengming Liu

    (Tulane National Primate Research Center
    Tulane University School of Medicine
    Temple University Lewis Katz School of Medicine)

  • Shen Dai

    (Temple University Lewis Katz School of Medicine)

  • Dechun Feng

    (National Institutes of Health)

  • Zhongnan Qin

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Xiao Peng

    (Temple University Lewis Katz School of Medicine)

  • Siva S. V. P. Sakamuri

    (Tulane University School of Medicine)

  • Mi Ren

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Li Huang

    (Temple University Lewis Katz School of Medicine)

  • Min Cheng

    (Temple University Lewis Katz School of Medicine)

  • Kabir E. Mohammad

    (Tulane National Primate Research Center
    Tulane University School of Medicine)

  • Ping Qu

    (Temple University Lewis Katz School of Medicine)

  • Yong Chen

    (Temple University Lewis Katz School of Medicine)

  • Chunling Zhao

    (Temple University Lewis Katz School of Medicine)

  • Faliang Zhu

    (Temple University Lewis Katz School of Medicine)

  • Shujian Liang

    (Temple University Lewis Katz School of Medicine)

  • Bertal H. Aktas

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Xiaofeng Yang

    (Temple University Lewis Katz School of Medicine)

  • Hong Wang

    (Temple University Lewis Katz School of Medicine)

  • Prasad V. G. Katakam

    (Tulane University School of Medicine)

  • David W. Busija

    (Tulane University School of Medicine)

  • Tracy Fischer

    (Tulane National Primate Research Center)

  • Prasun K. Datta

    (Temple University Lewis Katz School of Medicine
    Tulane National Primate Research Center)

  • Jay Rappaport

    (Tulane National Primate Research Center)

  • Bin Gao

    (National Institutes of Health)

  • Xuebin Qin

    (Tulane National Primate Research Center
    Tulane University School of Medicine
    Temple University Lewis Katz School of Medicine)

Abstract

Renal macrophages (RMs) participate in tissue homeostasis, inflammation and repair. RMs consist of embryo-derived (EMRMs) and bone marrow-derived RMs (BMRMs), but the fate, dynamics, replenishment, functions and metabolic states of these two RM populations remain unclear. Here we investigate and characterize RMs at different ages by conditionally labeling and ablating RMs populations in several transgenic lines. We find that RMs expand and mature in parallel with renal growth after birth, and are mainly derived from fetal liver monocytes before birth, but self-maintain through adulthood with contribution from peripheral monocytes. Moreover, after the RMs niche is emptied, peripheral monocytes rapidly differentiate into BMRMs, with the CX3CR1/CX3CL1 signaling axis being essential for the maintenance and regeneration of both EMRMs and BMRMs. Lastly, we show that EMRMs have a higher capacity for scavenging immune complex, and are more sensitive to immune challenge than BMRMs, with this difference associated with their distinct glycolytic capacities.

Suggested Citation

  • Fengming Liu & Shen Dai & Dechun Feng & Zhongnan Qin & Xiao Peng & Siva S. V. P. Sakamuri & Mi Ren & Li Huang & Min Cheng & Kabir E. Mohammad & Ping Qu & Yong Chen & Chunling Zhao & Faliang Zhu & Shuj, 2020. "Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16158-z
    DOI: 10.1038/s41467-020-16158-z
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    Cited by:

    1. Caitriona M. McEvoy & Julia M. Murphy & Lin Zhang & Sergi Clotet-Freixas & Jessica A. Mathews & James An & Mehran Karimzadeh & Delaram Pouyabahar & Shenghui Su & Olga Zaslaver & Hannes Röst & Rangi Ar, 2022. "Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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