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A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia

Author

Listed:
  • Junhua Ding

    (Beijing Normal University
    Baylor College of Medicine)

  • Keliang Chen

    (Huashan Hospital, Fudan University)

  • Haoming Liu

    (Ca’ Foscari University of Venice)

  • Lin Huang

    (Shanghai Jiaotong University Affiliated Sixth People’s Hospital)

  • Yan Chen

    (Beijing Normal University
    Zhejiang University)

  • Yingru Lv

    (Huashan Hospital, Fudan University)

  • Qing Yang

    (Huashan Hospital, Fudan University)

  • Qihao Guo

    (Shanghai Jiaotong University Affiliated Sixth People’s Hospital)

  • Zaizhu Han

    (Beijing Normal University)

  • Matthew. A. Lambon Ralph

    (University of Cambridge)

Abstract

The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and map these to the patients’ distribution of frontotemporal atrophy. Here we show that the degree of generalised semantic impairment is related to the patients’ total, bilateral ATL atrophy. Verbal production ability is related to total ATL atrophy as well as to the balance of left > right ATL atrophy. Apathy is found to relate positively to the degree of orbitofrontal atrophy. Disinhibition is related to right ATL and orbitofrontal atrophy, and face recognition to right ATL volumes. Rather than positing mutually-exclusive sub-categories, the data-driven model repositions semantics, language, social behaviour and face recognition into a continuous frontotemporal neurocognitive space.

Suggested Citation

  • Junhua Ding & Keliang Chen & Haoming Liu & Lin Huang & Yan Chen & Yingru Lv & Qing Yang & Qihao Guo & Zaizhu Han & Matthew. A. Lambon Ralph, 2020. "A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16089-9
    DOI: 10.1038/s41467-020-16089-9
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    Cited by:

    1. Elliot Murphy & Kiefer J. Forseth & Cristian Donos & Kathryn M. Snyder & Patrick S. Rollo & Nitin Tandon, 2023. "The spatiotemporal dynamics of semantic integration in the human brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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