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Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone

Author

Listed:
  • Katrina L. Adams

    (Children’s National Hospital)

  • Giulia Riparini

    (Children’s National Hospital
    University of Urbino “Carlo Bo”)

  • Payal Banerjee

    (Children’s National Hospital)

  • Marjolein Breur

    (VU University Medical Center)

  • Marianna Bugiani

    (VU University Medical Center)

  • Vittorio Gallo

    (Children’s National Hospital)

Abstract

Signaling molecules that regulate neurodevelopmental processes in the early postnatal subventricular zone (SVZ) are critical for proper brain development yet remain poorly characterized. Here, we report that Endothelin-1 (ET-1), a molecular component of the postnatal SVZ, promotes radial glial cell maintenance and proliferation in an autocrine manner via Notch signaling. Loss of ET-1 signaling increases neurogenesis and reduces oligodendrocyte progenitor cell proliferation (OPC) in the developing SVZ, thereby altering cellular output of the stem cell niche. We also show that ET-1 is required for increased neural stem cell and OPC proliferation in the adult mouse SVZ following demyelination. Lastly, high levels of ET-1 in the SVZ of patients with Cathepsin A-related arteriopathy with strokes and leukoencephalopathy correlate with an increased number of SVZ OPCs, suggesting ET-1’s role as a regulator of glial progenitor proliferation may be conserved in humans. ET-1 signaling therefore presents a potential new therapeutic target for promoting SVZ-mediated cellular repair.

Suggested Citation

  • Katrina L. Adams & Giulia Riparini & Payal Banerjee & Marjolein Breur & Marianna Bugiani & Vittorio Gallo, 2020. "Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16028-8
    DOI: 10.1038/s41467-020-16028-8
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    Cited by:

    1. Beata Jablonska & Katrina L. Adams & Panagiotis Kratimenos & Zhen Li & Emma Strickland & Tarik F. Haydar & Katharina Kusch & Klaus-Armin Nave & Vittorio Gallo, 2022. "Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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