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Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury

Author

Listed:
  • Sofia Meyer zu Reckendorf

    (Ulm University)

  • Christine Brand

    (Hospital Bogenhausen)

  • Maria T. Pedro

    (Ulm University, District Hospital)

  • Jutta Hegler

    (Ulm University)

  • Corinna S. Schilling

    (Ulm University)

  • Raissa Lerner

    (University Medical Centre of the Johannes Gutenberg University Mainz)

  • Laura Bindila

    (University Medical Centre of the Johannes Gutenberg University Mainz)

  • Gregor Antoniadis

    (Ulm University, District Hospital)

  • Bernd Knöll

    (Ulm University)

Abstract

Mammals differ in their regeneration potential after traumatic injury, which might be caused by species-specific regeneration programs. Here, we compared murine and human Schwann cell (SC) response to injury and developed an ex vivo injury model employing surgery-derived human sural nerves. Transcriptomic and lipid metabolism analysis of murine SCs following injury of sural nerves revealed down-regulation of lipogenic genes and regulator of lipid metabolism, including Pparg (peroxisome proliferator-activated receptor gamma) and S1P (sphingosine-1-phosphate). Human SCs failed to induce similar adaptations following ex vivo nerve injury. Pharmacological PPARg and S1P stimulation in mice resulted in up-regulation of lipid gene expression, suggesting a role in SCs switching towards a myelinating state. Altogether, our results suggest that murine SC switching towards a repair state is accompanied by transcriptome and lipidome adaptations, which are reduced in humans.

Suggested Citation

  • Sofia Meyer zu Reckendorf & Christine Brand & Maria T. Pedro & Jutta Hegler & Corinna S. Schilling & Raissa Lerner & Laura Bindila & Gregor Antoniadis & Bernd Knöll, 2020. "Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15915-4
    DOI: 10.1038/s41467-020-15915-4
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