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Mapping the spreading routes of lymphatic metastases in human colorectal cancer

Author

Listed:
  • Chong Zhang

    (Peking University)

  • Lin Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Tianlei Xu

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Ruidong Xue

    (Peking University)

  • Liang Yu

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yuelu Zhu

    (National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yunlong Wu

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Qingqing Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Dongdong Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Shuohao Shen

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Dongfeng Tan

    (The University of Texas M. D. Anderson Cancer Center)

  • Fan Bai

    (Peking University)

  • Haizeng Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How tumor cells disseminate within the lymphatic network remains largely unknown. Here, we analyze the subclonal structure of 94 tumor samples, covering the primary tumors, lymph node metastases (LNMs), and liver metastases from 10 CRC patients. We portray a high-resolution lymphatic metastatic map for CRC by dividing LNMs into paracolic, intermediate, and central subgroups. Among the 61 metastatic routes identified, 38 (62.3%) are initiated from the primary tumors, 22 (36.1%) from LNMs, and 1 from liver metastasis (1.6%). In 5 patients, we find 6 LNMs that reseed 2 or more LNMs. We summarize 3 diverse modes of metastasis in CRC and show that skip spreading of tumor cells within the lymphatic network is common. Our study sheds light on the complicated metastatic pattern in CRC and has great clinical implications.

Suggested Citation

  • Chong Zhang & Lin Zhang & Tianlei Xu & Ruidong Xue & Liang Yu & Yuelu Zhu & Yunlong Wu & Qingqing Zhang & Dongdong Li & Shuohao Shen & Dongfeng Tan & Fan Bai & Haizeng Zhang, 2020. "Mapping the spreading routes of lymphatic metastases in human colorectal cancer," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15886-6
    DOI: 10.1038/s41467-020-15886-6
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