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CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

Author

Listed:
  • Chikako Shimokawa

    (National Institute of Infectious Disease
    Gunma University
    RIKEN Center for Integrative Medical Sciences)

  • Tamotsu Kato

    (RIKEN Center for Integrative Medical Sciences
    Yokohama City University)

  • Tadashi Takeuchi

    (RIKEN Center for Integrative Medical Sciences
    Keio University)

  • Noriyasu Ohshima

    (Gunma University)

  • Takao Furuki

    (Center for Biological Resources and Informatics, Tokyo Institute of Technology)

  • Yoshiaki Ohtsu

    (Gunma University)

  • Kazutomo Suzue

    (Gunma University)

  • Takashi Imai

    (Gunma University)

  • Seiji Obi

    (Gunma University)

  • Alex Olia

    (National Institute of Infectious Disease
    Gunma University)

  • Takashi Izumi

    (Gunma University)

  • Minoru Sakurai

    (Center for Biological Resources and Informatics, Tokyo Institute of Technology)

  • Hirokazu Arakawa

    (Gunma University)

  • Hiroshi Ohno

    (RIKEN Center for Integrative Medical Sciences
    Yokohama City University
    Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology)

  • Hajime Hisaeda

    (National Institute of Infectious Disease
    Gunma University)

Abstract

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying regulatory mechanisms for this protection are unclear. Here, we report that CD8+ regulatory T (Treg) cells prevent the onset of streptozotocin -induced diabetes by a rodent intestinal nematode. Trehalose derived from nematodes affects the intestinal microbiota and increases the abundance of Ruminococcus spp., resulting in the induction of CD8+ Treg cells. Furthermore, trehalose has therapeutic effects on both streptozotocin-induced diabetes and in the NOD mouse model of T1D. In addition, compared with healthy volunteers, patients with T1D have fewer CD8+ Treg cells, and the abundance of intestinal Ruminococcus positively correlates with the number of CD8+ Treg cells in humans.

Suggested Citation

  • Chikako Shimokawa & Tamotsu Kato & Tadashi Takeuchi & Noriyasu Ohshima & Takao Furuki & Yoshiaki Ohtsu & Kazutomo Suzue & Takashi Imai & Seiji Obi & Alex Olia & Takashi Izumi & Minoru Sakurai & Hiroka, 2020. "CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15857-x
    DOI: 10.1038/s41467-020-15857-x
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