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Dynamic states of population activity in prefrontal cortical networks of freely-moving macaque

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  • Russell Milton

    (University of Texas)

  • Neda Shahidi

    (University of Texas)

  • Valentin Dragoi

    (University of Texas
    Rice University)

Abstract

Neural responses in the cerebral cortex change dramatically between the ‘synchronized’ state during sleep and ‘desynchronized’ state during wakefulness. Our understanding of cortical state emerges largely from experiments performed in sensory areas of head-fixed or tethered rodents due to technical limitations of recording from larger freely-moving animals for several hours. Here, we report a system integrating wireless electrophysiology, wireless eye tracking, and real-time video analysis to examine the dynamics of population activity in a high-level, executive area – dorsolateral prefrontal cortex (dlPFC) of unrestrained monkey. This technology allows us to identify cortical substates during quiet and active wakefulness, and transitions in population activity during rest. We further show that narrow-spiking neurons exhibit stronger synchronized fluctuations in population activity than broad-spiking neurons regardless of state. Our results show that cortical state is controlled by behavioral demands and arousal by asymmetrically modulating the slow response fluctuations of local excitatory and inhibitory cell populations.

Suggested Citation

  • Russell Milton & Neda Shahidi & Valentin Dragoi, 2020. "Dynamic states of population activity in prefrontal cortical networks of freely-moving macaque," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15803-x
    DOI: 10.1038/s41467-020-15803-x
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    Cited by:

    1. Sunny Nigam & Russell Milton & Sorin Pojoga & Valentin Dragoi, 2023. "Adaptive coding across visual features during free-viewing and fixation conditions," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Vishal Kapoor & Abhilash Dwarakanath & Shervin Safavi & Joachim Werner & Michel Besserve & Theofanis I. Panagiotaropoulos & Nikos K. Logothetis, 2022. "Decoding internally generated transitions of conscious contents in the prefrontal cortex without subjective reports," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Arun Parajuli & Diego Gutnisky & Nitin Tandon & Valentin Dragoi, 2023. "Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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