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Repurposing a chemosensory macromolecular machine

Author

Listed:
  • Davi R. Ortega

    (California Institute of Technology)

  • Wen Yang

    (Institute of Biology, Leiden University)

  • Poorna Subramanian

    (California Institute of Technology)

  • Petra Mann

    (Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology)

  • Andreas Kjær

    (California Institute of Technology
    Rex Richards Building)

  • Songye Chen

    (California Institute of Technology)

  • Kylie J. Watts

    (Division of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University)

  • Sahand Pirbadian

    (University of Southern California)

  • David A. Collins

    (Viral Information Institute, San Diego State University)

  • Romain Kooger

    (Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule Zürich)

  • Marina G. Kalyuzhnaya

    (Viral Information Institute, San Diego State University)

  • Simon Ringgaard

    (Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology)

  • Ariane Briegel

    (Institute of Biology, Leiden University)

  • Grant J. Jensen

    (California Institute of Technology
    California Institute of Technology)

Abstract

How complex, multi-component macromolecular machines evolved remains poorly understood. Here we reveal the evolutionary origins of the chemosensory machinery that controls flagellar motility in Escherichia coli. We first identify ancestral forms still present in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis and Methylomicrobium alcaliphilum, characterizing their structures by electron cryotomography and finding evidence that they function in a stress response pathway. Using bioinformatics, we trace the evolution of the system through γ-Proteobacteria, pinpointing key evolutionary events that led to the machine now seen in E. coli. Our results suggest that two ancient chemosensory systems with different inputs and outputs (F6 and F7) existed contemporaneously, with one (F7) ultimately taking over the inputs and outputs of the other (F6), which was subsequently lost.

Suggested Citation

  • Davi R. Ortega & Wen Yang & Poorna Subramanian & Petra Mann & Andreas Kjær & Songye Chen & Kylie J. Watts & Sahand Pirbadian & David A. Collins & Romain Kooger & Marina G. Kalyuzhnaya & Simon Ringgaar, 2020. "Repurposing a chemosensory macromolecular machine," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15736-5
    DOI: 10.1038/s41467-020-15736-5
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