IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-15700-3.html
   My bibliography  Save this article

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Author

Listed:
  • Fanlei Hu

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
    Peking University)

  • Xiang Jiang

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
    Peking University)

  • Chunqing Guo

    (Virginia Commonwealth University, School of Medicine
    Virginia Commonwealth University, School of Medicine
    Virginia Commonwealth University, School of Medicine)

  • Yingni Li

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Shixian Chen

    (Southern Medical University
    Southern Medical University)

  • Wei Zhang

    (First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity)

  • Yan Du

    (Zhejiang University School of Medicine)

  • Ping Wang

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Xi Zheng

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
    Peking University)

  • Xiangyu Fang

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Xin Li

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
    Peking University)

  • Jing Song

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
    Peking University)

  • Yang Xie

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Fei Huang

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Jimeng Xue

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Mingxin Bai

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Yuan Jia

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Xu Liu

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Limin Ren

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Xiaoying Zhang

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Jianping Guo

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Hudan Pan

    (Macau University of Science and Technology)

  • Yin Su

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Huanfa Yi

    (Virginia Commonwealth University, School of Medicine
    The First Hospital of Jilin University)

  • Hua Ye

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Daming Zuo

    (Virginia Commonwealth University, School of Medicine
    Southern Medical University)

  • Juan Li

    (Southern Medical University
    Southern Medical University)

  • Huaxiang Wu

    (Zhejiang University School of Medicine)

  • Yongfu Wang

    (First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity)

  • Ru Li

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135))

  • Liang Liu

    (Macau University of Science and Technology)

  • Xiang-Yang Wang

    (Virginia Commonwealth University, School of Medicine
    Virginia Commonwealth University, School of Medicine
    Virginia Commonwealth University, School of Medicine)

  • Zhanguo Li

    (Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
    Peking University
    Peking University)

Abstract

Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.

Suggested Citation

  • Fanlei Hu & Xiang Jiang & Chunqing Guo & Yingni Li & Shixian Chen & Wei Zhang & Yan Du & Ping Wang & Xi Zheng & Xiangyu Fang & Xin Li & Jing Song & Yang Xie & Fei Huang & Jimeng Xue & Mingxin Bai & Yu, 2020. "Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15700-3
    DOI: 10.1038/s41467-020-15700-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-15700-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-15700-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15700-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.