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Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Author

Listed:
  • Kay H. M. Roumans

    (Maastricht University)

  • Lucas Lindeboom

    (Maastricht University
    Maastricht University Medical Center)

  • Pandichelvam Veeraiah

    (Maastricht University
    Maastricht University Medical Center)

  • Carlijn M. E. Remie

    (Maastricht University)

  • Esther Phielix

    (Maastricht University)

  • Bas Havekes

    (Maastricht University Medical Center)

  • Yvonne M. H. Bruls

    (Maastricht University
    Maastricht University Medical Center)

  • Martijn C. G. J. Brouwers

    (Maastricht University Medical Center)

  • Marcus Ståhlman

    (University of Gothenburg, and Sahlgrenska University Hospital)

  • Marjan Alssema

    (Unilever Food Innovation Center)

  • Harry P. F. Peters

    (Unilever Food Innovation Center)

  • Renée Mutsert

    (Leiden University Medical Center)

  • Bart Staels

    (Institut Pasteur de Lille)

  • Marja-Riitta Taskinen

    (University of Helsinki)

  • Jan Borén

    (University of Gothenburg, and Sahlgrenska University Hospital)

  • Patrick Schrauwen

    (Maastricht University)

  • Vera B. Schrauwen-Hinderling

    (Maastricht University
    Maastricht University Medical Center)

Abstract

Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.

Suggested Citation

  • Kay H. M. Roumans & Lucas Lindeboom & Pandichelvam Veeraiah & Carlijn M. E. Remie & Esther Phielix & Bas Havekes & Yvonne M. H. Bruls & Martijn C. G. J. Brouwers & Marcus Ståhlman & Marjan Alssema & H, 2020. "Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15684-0
    DOI: 10.1038/s41467-020-15684-0
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