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Sex-associated molecular differences for cancer immunotherapy

Author

Listed:
  • Youqiong Ye

    (Shanghai Jiao Tong University School of Medicine
    The University of Texas Health Science Center at Houston McGovern Medical School)

  • Ying Jing

    (The University of Texas Health Science Center at Houston McGovern Medical School)

  • Liang Li

    (The University of Texas MD Anderson Cancer Center)

  • Gordon B. Mills

    (Oregon Health and Science University)

  • Lixia Diao

    (The University of Texas MD Anderson Cancer Center)

  • Hong Liu

    (Central South University)

  • Leng Han

    (The University of Texas Health Science Center at Houston McGovern Medical School
    The University of Texas Health Science Center at Houston)

Abstract

Immune checkpoint blockade therapies have extended patient survival across multiple cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is different between male and female patients. We summarize the existing meta-analysis to show inconsistent conclusions for whether gender is associated with the immunotherapy response. We analyze molecular profiling from ICB-treated patients to identify molecular differences for immunotherapy responsiveness. We perform comprehensive analyses for patients from The Cancer Genome Atlas (TCGA) and reveal divergent patterns for sex bias in immune features across multiple cancer types. We further validate our observations in multiple independent data sets. Considering that the majority of clinical trials are in melanoma and lung cancer, meta-analyses that pool multiple cancer types have limitations to discern whether cancer immunotherapy efficacy is different between male and female patients. Future studies should include omics profiling to investigate sex-associated molecular differences in immunotherapy.

Suggested Citation

  • Youqiong Ye & Ying Jing & Liang Li & Gordon B. Mills & Lixia Diao & Hong Liu & Leng Han, 2020. "Sex-associated molecular differences for cancer immunotherapy," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15679-x
    DOI: 10.1038/s41467-020-15679-x
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    Cited by:

    1. Mei Luo & Lin Ye & Ruimin Chang & Youqiong Ye & Zhao Zhang & Chunjie Liu & Shengli Li & Ying Jing & Hang Ruan & Guanxiong Zhang & Yi He & Yaoming Liu & Yu Xue & Xiang Chen & An-Yuan Guo & Hong Liu & L, 2022. "Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Ashwin V. Kammula & Alejandro A. Schäffer & Padma Sheila Rajagopal & Razelle Kurzrock & Eytan Ruppin, 2024. "Outcome differences by sex in oncology clinical trials," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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