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Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains

Author

Listed:
  • Kyra T. Newmaster

    (Penn State University)

  • Zachary T. Nolan

    (Penn State University)

  • Uree Chon

    (Penn State University)

  • Daniel J. Vanselow

    (Penn State University
    Penn State University)

  • Abigael R. Weit

    (Penn State University)

  • Manal Tabbaa

    (Florida State University)

  • Shizu Hidema

    (Tohoku University Graduate School of Agricultural Science
    Fukushima Medical University)

  • Katsuhiko Nishimori

    (Tohoku University Graduate School of Agricultural Science
    Fukushima Medical University)

  • Elizabeth A. D. Hammock

    (Florida State University)

  • Yongsoo Kim

    (Penn State University)

Abstract

The oxytocin receptor (OTR) plays critical roles in social behavior development. Despite its significance, brain-wide quantitative understanding of OTR expression remains limited in postnatally developing brains. Here, we develop postnatal 3D template brains to register whole brain images with cellular resolution to systematically quantify OTR cell densities. We utilize fluorescent reporter mice (Otrvenus/+) and find that cortical regions show temporally and spatially heterogeneous patterns with transient postnatal OTR expression without cell death. Cortical OTR cells are largely glutamatergic neurons with the exception of cells in layer 6b. Subcortical regions show similar temporal regulation except the hypothalamus and two hypothalamic nuclei display sexually dimorphic OTR expression. Lack of OTR expression correlates with reduced dendritic spine densities in selected cortical regions of developing brains. Lastly, we create a website to visualize our high-resolution imaging data. In summary, our research provides a comprehensive resource for postnatal OTR expression in the mouse brain.

Suggested Citation

  • Kyra T. Newmaster & Zachary T. Nolan & Uree Chon & Daniel J. Vanselow & Abigael R. Weit & Manal Tabbaa & Shizu Hidema & Katsuhiko Nishimori & Elizabeth A. D. Hammock & Yongsoo Kim, 2020. "Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15659-1
    DOI: 10.1038/s41467-020-15659-1
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    Cited by:

    1. Masafumi Tsurutani & Teppei Goto & Mitsue Hagihara & Satsuki Irie & Kazunari Miyamichi, 2024. "Selective vulnerability of parvocellular oxytocin neurons in social dysfunction," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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