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Fatal heart disease among cancer patients

Author

Listed:
  • Kelsey C. Stoltzfus

    (Penn State Cancer Institute)

  • Ying Zhang

    (Biostatistics and Research Decision Sciences, Merck & Co)

  • Kathleen Sturgeon

    (Penn State College of Medicine)

  • Lawrence I. Sinoway

    (Penn State College of Medicine)

  • Daniel M. Trifiletti

    (Mayo Clinic)

  • Vernon M. Chinchilli

    (Penn State College of Medicine)

  • Nicholas G. Zaorsky

    (Penn State Cancer Institute
    Penn State College of Medicine)

Abstract

As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer patients at highest risk of fatal heart disease compared to the general population and other cancer patients at risk of death during the study time period. Here we report that 394,849 of the 7,529,481 cancer patients studied died of heart disease. The heart disease-specific mortality rate is 10.61/10,000-person years, and the standardized mortality ratio (SMR) of fatal heart disease is 2.24 (95% CI: 2.23–2.25). Compared to other cancer patients, patients who are older, male, African American, and unmarried are at a greatest risk of fatal heart disease. For almost all cancer survivors, the risk of fatal heart disease increases with time.

Suggested Citation

  • Kelsey C. Stoltzfus & Ying Zhang & Kathleen Sturgeon & Lawrence I. Sinoway & Daniel M. Trifiletti & Vernon M. Chinchilli & Nicholas G. Zaorsky, 2020. "Fatal heart disease among cancer patients," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15639-5
    DOI: 10.1038/s41467-020-15639-5
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    Cited by:

    1. Kyle Mani & Daxuan Deng & Christine Lin & Ming Wang & Melinda L. Hsu & Nicholas G. Zaorsky, 2024. "Causes of death among people living with metastatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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