IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-15578-1.html
   My bibliography  Save this article

FBXO22 degrades nuclear PTEN to promote tumorigenesis

Author

Listed:
  • Meng-Kai Ge

    (Shanghai Jiao Tong University School of Medicine)

  • Na Zhang

    (Shanghai Jiao Tong University School of Medicine)

  • Li Xia

    (Shanghai Jiao Tong University School of Medicine)

  • Cheng Zhang

    (Shanghai Jiao Tong University School of Medicine)

  • Shuang-Shu Dong

    (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Zhan-Ming Li

    (Shanghai Jiao Tong University School of Medicine)

  • Yan Ji

    (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Min-Hua Zheng

    (Shanghai Jiao Tong University School of Medicine)

  • Jing Sun

    (Shanghai Jiao Tong University School of Medicine)

  • Guo-Qiang Chen

    (Shanghai Jiao Tong University School of Medicine)

  • Shao-Ming Shen

    (Shanghai Jiao Tong University School of Medicine)

Abstract

Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than cytoplasmic PTEN, here we identify that F-box only protein 22 (FBXO22) induces ubiquitylation of nuclear but not cytoplasmic PTEN at lysine 221, which is responsible for the degradation of nuclear PTEN. FBXO22 plays a tumor-promoting role by ubiquitylating and degrading nuclear PTEN. In accordance, FBXO22 is overexpressed in various cancer types, and contributes to nuclear PTEN downregulation in colorectal cancer tissues. Cumulatively, our study reports the mechanism to specifically regulate the stability of nuclear PTEN, which would provide the opportunity for developing therapeutic strategies aiming to achieve complete reactivation of PTEN as a tumor suppressor.

Suggested Citation

  • Meng-Kai Ge & Na Zhang & Li Xia & Cheng Zhang & Shuang-Shu Dong & Zhan-Ming Li & Yan Ji & Min-Hua Zheng & Jing Sun & Guo-Qiang Chen & Shao-Ming Shen, 2020. "FBXO22 degrades nuclear PTEN to promote tumorigenesis," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15578-1
    DOI: 10.1038/s41467-020-15578-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-15578-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-15578-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lili Zhao & Yuxin An & Nan Zhao & Hang Gao & Weijie Zhang & Zhou Gong & Xiaolong Liu & Baofeng Zhao & Zhen Liang & Chun Tang & Lihua Zhang & Yukui Zhang & Qun Zhao, 2024. "Spatially resolved profiling of protein conformation and interactions by biocompatible chemical cross-linking in living cells," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15578-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.