IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-15569-2.html
   My bibliography  Save this article

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

Author

Listed:
  • Bingfeng Zuo

    (Tianjin Medical University)

  • Han Qi

    (Tianjin Medical University)

  • Zhen Lu

    (Tianjin Medical University)

  • Lu Chen

    (Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy)

  • Bo Sun

    (Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy)

  • Rong Yang

    (Huazhong University of Science and Technology)

  • Yang Zhang

    (Tianjin Medical University)

  • Zhili Liu

    (Tianjin Medical University)

  • Xianjun Gao

    (Tianjin Medical University)

  • Abin You

    (Tianjin Medical University)

  • Li Wu

    (Tianjin Medical University)

  • Renwei Jing

    (Tianjin Medical University)

  • Qibing Zhou

    (Huazhong University of Science and Technology)

  • HaiFang Yin

    (Tianjin Medical University)

Abstract

Treating large established tumors is challenging for dendritic cell (DC)-based immunotherapy. DC activation with tumor cell-derived exosomes (TEXs) carrying multiple tumor-associated antigen can enhance tumor recognition. Adding a potent adjuvant, high mobility group nucleosome-binding protein 1 (HMGN1), boosts DCs’ ability to activate T cells and improves vaccine efficiency. Here, we demonstrate that TEXs painted with the functional domain of HMGN1 (TEX-N1ND) via an exosomal anchor peptide potentiates DC immunogenicity. TEX-N1ND pulsed DCs (DCTEX-N1ND) elicit long-lasting antitumor immunity and tumor suppression in different syngeneic mouse models with large tumor burdens, most notably large, poorly immunogenic orthotopic hepatocellular carcinoma (HCC). DCTEX-N1ND show increased homing to lymphoid tissues and contribute to augmented memory T cells. Importantly, N1ND-painted serum exosomes from cancer patients also promote DC activation. Our study demonstrates the potency of TEX-N1ND to strengthen DC immunogenicity and to suppress large established tumors, and thus provides an avenue to improve DC-based immunotherapy.

Suggested Citation

  • Bingfeng Zuo & Han Qi & Zhen Lu & Lu Chen & Bo Sun & Rong Yang & Yang Zhang & Zhili Liu & Xianjun Gao & Abin You & Li Wu & Renwei Jing & Qibing Zhou & HaiFang Yin, 2020. "Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15569-2
    DOI: 10.1038/s41467-020-15569-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-15569-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-15569-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiaoqiong Zhang & Zhaohan Wei & Tuying Yong & Shiyu Li & Nana Bie & Jianye Li & Xin Li & Haojie Liu & Hang Xu & Yuchen Yan & Bixiang Zhang & Xiaoping Chen & Xiangliang Yang & Lu Gan, 2023. "Cell microparticles loaded with tumor antigen and resiquimod reprogram tumor-associated macrophages and promote stem-like CD8+ T cells to boost anti-PD-1 therapy," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Rimsha Bhatta & Joonsu Han & Yusheng Liu & Yang Bo & David Lee & Jiadiao Zhou & Yueji Wang & Erik Russell Nelson & Qian Chen & Xiaojia Shelly Zhang & Wael Hassaneen & Hua Wang, 2023. "Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15569-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.