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Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

Author

Listed:
  • Yordi J. Vegte

    (University of Groningen, University Medical Center Groningen)

  • M. Abdullah Said

    (University of Groningen, University Medical Center Groningen)

  • Michiel Rienstra

    (University of Groningen, University Medical Center Groningen)

  • Pim Harst

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen
    Netherlands Heart Institute
    University Medical Center Utrecht)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen
    Genomics plc)

Abstract

Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronary artery disease (CAD). Genome wide association analyses of leisure television watching, leisure computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci (P

Suggested Citation

  • Yordi J. Vegte & M. Abdullah Said & Michiel Rienstra & Pim Harst & Niek Verweij, 2020. "Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15553-w
    DOI: 10.1038/s41467-020-15553-w
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