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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

Author

Listed:
  • Joana A. Revez

    (The University of Queensland)

  • Tian Lin

    (The University of Queensland)

  • Zhen Qiao

    (The University of Queensland)

  • Angli Xue

    (The University of Queensland)

  • Yan Holtz

    (The University of Queensland)

  • Zhihong Zhu

    (The University of Queensland)

  • Jian Zeng

    (The University of Queensland)

  • Huanwei Wang

    (The University of Queensland)

  • Julia Sidorenko

    (The University of Queensland)

  • Kathryn E. Kemper

    (The University of Queensland)

  • Anna A. E. Vinkhuyzen

    (The University of Queensland)

  • Julanne Frater

    (The University of Queensland)

  • Darryl Eyles

    (The University of Queensland
    The Park Centre for Mental Health)

  • Thomas H. J. Burne

    (The University of Queensland
    The Park Centre for Mental Health)

  • Brittany Mitchell

    (QIMR Berghofer Medical Research Institute
    Queensland University of Technology)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Gu Zhu

    (QIMR Berghofer Medical Research Institute)

  • Peter M. Visscher

    (The University of Queensland)

  • Jian Yang

    (The University of Queensland
    Wenzhou Medical University)

  • Naomi R. Wray

    (The University of Queensland
    The University of Queensland)

  • John J. McGrath

    (The University of Queensland
    The Park Centre for Mental Health
    Aarhus University)

Abstract

Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.

Suggested Citation

  • Joana A. Revez & Tian Lin & Zhen Qiao & Angli Xue & Yan Holtz & Zhihong Zhu & Jian Zeng & Huanwei Wang & Julia Sidorenko & Kathryn E. Kemper & Anna A. E. Vinkhuyzen & Julanne Frater & Darryl Eyles & T, 2020. "Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15421-7
    DOI: 10.1038/s41467-020-15421-7
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    Cited by:

    1. William R. Reay & Dylan J. Kiltschewskij & Maria A. Biase & Zachary F. Gerring & Kousik Kundu & Praveen Surendran & Laura A. Greco & Erin D. Clarke & Clare E. Collins & Alison M. Mondul & Demetrius Al, 2024. "Genetic influences on circulating retinol and its relationship to human health," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Benjamin M. Jacobs & Daniel Stow & Sam Hodgson & Julia Zöllner & Miriam Samuel & Stavroula Kanoni & Saeed Bidi & Klaudia Walter & Claudia Langenberg & Ruth Dobson & Sarah Finer & Caroline Morton & Mon, 2024. "Genetic architecture of routinely acquired blood tests in a British South Asian cohort," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Clara Albiñana & Zhihong Zhu & Nis Borbye-Lorenzen & Sanne Grundvad Boelt & Arieh S. Cohen & Kristin Skogstrand & Naomi R. Wray & Joana A. Revez & Florian Privé & Liselotte V. Petersen & Cynthia M. Bu, 2023. "Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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