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Nitric oxide as a source for bacterial triazole biosynthesis

Author

Listed:
  • Guiyun Zhao

    (Zhejiang University School of Medicine)

  • Yuan-Yang Guo

    (Henan Normal University)

  • Shunyu Yao

    (Zhejiang University School of Medicine)

  • Xinjie Shi

    (Zhejiang University School of Medicine)

  • Longxian Lv

    (Zhejiang University)

  • Yi-Ling Du

    (Zhejiang University School of Medicine
    Zhejiang University)

Abstract

The heterocycle 1,2,3-triazole is among the most versatile chemical scaffolds and has been widely used in diverse fields. However, how nature creates this nitrogen-rich ring system remains unknown. Here, we report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine. We reveal that its triazole moiety can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is used as a building block. These results expand our knowledge of the physiological role of nitric oxide synthase in building natural products with a nitrogen–nitrogen bond, and should also inspire the development of synthetic biology approaches for triazole production.

Suggested Citation

  • Guiyun Zhao & Yuan-Yang Guo & Shunyu Yao & Xinjie Shi & Longxian Lv & Yi-Ling Du, 2020. "Nitric oxide as a source for bacterial triazole biosynthesis," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15420-8
    DOI: 10.1038/s41467-020-15420-8
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    Cited by:

    1. Guiyun Zhao & Wei Peng & Kaihui Song & Jingkun Shi & Xingyu Lu & Binju Wang & Yi-Ling Du, 2021. "Molecular basis of enzymatic nitrogen-nitrogen formation by a family of zinc-binding cupin enzymes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.

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