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Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Author

Listed:
  • Kathy Y. Liu

    (University College London)

  • Rogier A. Kievit

    (University of Cambridge)

  • Kamen A. Tsvetanov

    (Cambridge Centre for Ageing and Neuroscience (Cam-CAN), University of Cambridge and MRC Cognition and Brain Sciences Unit
    University of Cambridge
    University of Cambridge)

  • Matthew J. Betts

    (German Center for Neurodegenerative Diseases (DZNE)
    Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg
    Center for Behavioral Brain Sciences)

  • Emrah Düzel

    (German Center for Neurodegenerative Diseases (DZNE)
    Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg
    University College London)

  • James B. Rowe

    (University of Cambridge
    Cambridge Centre for Ageing and Neuroscience (Cam-CAN), University of Cambridge and MRC Cognition and Brain Sciences Unit
    University of Cambridge)

  • Robert Howard

    (University College London)

  • Dorothea Hämmerer

    (German Center for Neurodegenerative Diseases (DZNE)
    Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg
    Center for Behavioral Brain Sciences
    University College London)

Abstract

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function.

Suggested Citation

  • Kathy Y. Liu & Rogier A. Kievit & Kamen A. Tsvetanov & Matthew J. Betts & Emrah Düzel & James B. Rowe & Robert Howard & Dorothea Hämmerer, 2020. "Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15410-w
    DOI: 10.1038/s41467-020-15410-w
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    Cited by:

    1. Prokopis C. Prokopiou & Nina Engels-Domínguez & Kathryn V. Papp & Matthew R. Scott & Aaron P. Schultz & Christoph Schneider & Michelle E. Farrell & Rachel F. Buckley & Yakeel T. Quiroz & Georges El Fa, 2022. "Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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