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The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism

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  • Brice de la Crompe

    (Université de Bordeaux, Institut des Maladies Neurodégénératives
    CNRS UMR 5293, Institut des Maladies Neurodégénératives)

  • Asier Aristieta

    (Université de Bordeaux, Institut des Maladies Neurodégénératives
    CNRS UMR 5293, Institut des Maladies Neurodégénératives)

  • Arthur Leblois

    (Université de Bordeaux, Institut des Maladies Neurodégénératives
    CNRS UMR 5293, Institut des Maladies Neurodégénératives)

  • Salma Elsherbiny

    (Université de Bordeaux, Institut des Maladies Neurodégénératives
    CNRS UMR 5293, Institut des Maladies Neurodégénératives)

  • Thomas Boraud

    (Université de Bordeaux, Institut des Maladies Neurodégénératives
    CNRS UMR 5293, Institut des Maladies Neurodégénératives)

  • Nicolas P. Mallet

    (Université de Bordeaux, Institut des Maladies Neurodégénératives
    CNRS UMR 5293, Institut des Maladies Neurodégénératives)

Abstract

The dynamical properties of cortico-basal ganglia (CBG) circuits are dramatically altered following the loss of dopamine in Parkinson’s disease (PD). The neural circuit dysfunctions associated with PD include spike-rate alteration concomitant with excessive oscillatory spike-synchronization in the beta frequency range (12–30 Hz). Which neuronal circuits orchestrate and propagate these abnormal neural dynamics in CBG remains unknown. In this work, we combine in vivo electrophysiological recordings with advanced optogenetic manipulations in normal and 6-OHDA rats to shed light on the mechanistic principle underlying circuit dysfunction in PD. Our results show that abnormal neural dynamics present in a rat model of PD do not rely on cortical or subthalamic nucleus activity but critically dependent on globus pallidus (GP) integrity. Our findings highlight the pivotal role played by the GP which operates as a hub nucleus capable of orchestrating firing rate and synchronization changes across CBG circuits both in normal and pathological conditions.

Suggested Citation

  • Brice de la Crompe & Asier Aristieta & Arthur Leblois & Salma Elsherbiny & Thomas Boraud & Nicolas P. Mallet, 2020. "The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15352-3
    DOI: 10.1038/s41467-020-15352-3
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    Cited by:

    1. Leon A. Steiner & David Crompton & Srdjan Sumarac & Artur Vetkas & Jürgen Germann & Maximilian Scherer & Maria Justich & Alexandre Boutet & Milos R. Popovic & Mojgan Hodaie & Suneil K. Kalia & Alfonso, 2024. "Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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