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An acid-tolerance response system protecting exponentially growing Escherichia coli

Author

Listed:
  • Ying Xu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhe Zhao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wenhua Tong

    (Chinese Academy of Sciences
    Sichuan University of Science and Engineering)

  • Yamei Ding

    (Chinese Academy of Sciences)

  • Bin Liu

    (Nankai University, TEDA)

  • Yixin Shi

    (Arizona State University)

  • Jichao Wang

    (Chinese Academy of Sciences)

  • Shenmei Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Min Liu

    (Chinese Academy of Sciences)

  • Yuhui Wang

    (Nankai University, TEDA)

  • Qingsheng Qi

    (Shandong University)

  • Mo Xian

    (Chinese Academy of Sciences)

  • Guang Zhao

    (Chinese Academy of Sciences
    Shandong University)

Abstract

The ability to grow at moderate acidic conditions (pH 4.0–5.0) is important to Escherichia coli colonization of the host’s intestine. Several regulatory systems are known to control acid resistance in E. coli, enabling the bacteria to survive under acidic conditions without growth. Here, we characterize an acid-tolerance response (ATR) system and its regulatory circuit, required for E. coli exponential growth at pH 4.2. A two-component system CpxRA directly senses acidification through protonation of CpxA periplasmic histidine residues, and upregulates the fabA and fabB genes, leading to increased production of unsaturated fatty acids. Changes in lipid composition decrease membrane fluidity, F0F1-ATPase activity, and improve intracellular pH homeostasis. The ATR system is important for E. coli survival in the mouse intestine and for production of higher level of 3-hydroxypropionate during fermentation. Furthermore, this ATR system appears to be conserved in other Gram-negative bacteria.

Suggested Citation

  • Ying Xu & Zhe Zhao & Wenhua Tong & Yamei Ding & Bin Liu & Yixin Shi & Jichao Wang & Shenmei Sun & Min Liu & Yuhui Wang & Qingsheng Qi & Mo Xian & Guang Zhao, 2020. "An acid-tolerance response system protecting exponentially growing Escherichia coli," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15350-5
    DOI: 10.1038/s41467-020-15350-5
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    Cited by:

    1. Wang, Kai & Da, Yangyang & Bi, Haoran & Liu, Yanhui & Chen, Biqiang & Wang, Meng & Liu, Zihe & Nielsen, Jens & Tan, Tianwei, 2023. "A one-carbon chemicals conversion strategy to produce precursor of biofuels with Saccharomyces cerevisiae," Renewable Energy, Elsevier, vol. 208(C), pages 331-340.
    2. Jinzhong Tian & Wangshuying Deng & Ziwen Zhang & Jiaqi Xu & Guiling Yang & Guoping Zhao & Sheng Yang & Weihong Jiang & Yang Gu, 2023. "Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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