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The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Author

Listed:
  • Matthias I. Gröschel

    (Molecular and Experimental Mycobacteriology, Research Center Borstel
    University Medical Center Groningen, University of Groningen)

  • Conor J. Meehan

    (School of Chemistry and Bioscience, University of Bradford)

  • Ivan Barilar

    (Molecular and Experimental Mycobacteriology, Research Center Borstel)

  • Margo Diricks

    (bioMérieux, Applied Maths NV, Keistraat 120)

  • Aitor Gonzaga

    (Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures)

  • Matthias Steglich

    (Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures)

  • Oscar Conchillo-Solé

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona)

  • Isabell-Christin Scherer

    (University Hospital Schleswig-Holstein)

  • Uwe Mamat

    (Cellular Microbiology, Research Center Borstel)

  • Christian F. Luz

    (University Medical Center Groningen, University of Groningen)

  • Katrien Bruyne

    (bioMérieux, Applied Maths NV, Keistraat 120)

  • Christian Utpatel

    (Molecular and Experimental Mycobacteriology, Research Center Borstel)

  • Daniel Yero

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona)

  • Isidre Gibert

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona)

  • Xavier Daura

    (Universitat Autònoma de Barcelona
    Catalan Institution for Research and Advanced Studies)

  • Stefanie Kampmeier

    (University Hospital Münster)

  • Nurdyana Abdul Rahman

    (Singapore General Hospital)

  • Michael Kresken

    (Antiinfectives Intelligence GmbH
    Rheinische Fachhochschule Köln gGmbH)

  • Tjip S. Werf

    (University Medical Center Groningen, University of Groningen)

  • Ifey Alio

    (University of Hamburg)

  • Wolfgang R. Streit

    (University of Hamburg)

  • Kai Zhou

    (Southern University of Science and Technology
    Jinan University)

  • Thomas Schwartz

    (Karlsruhe Institute of Technology, Institute of Functional Interfaces)

  • John W. A. Rossen

    (University Medical Center Groningen, University of Groningen)

  • Maha R. Farhat

    (Department of Biomedical Informatics, Harvard Medical School
    Massachusetts General Hospital)

  • Ulrich E. Schaible

    (Cellular Microbiology, Research Center Borstel
    German Center for Infection Research (DZIF), partner site Hamburg - Lübeck - Borstel - Riems
    Leibniz Research Alliance INFECTIONS’21)

  • Ulrich Nübel

    (Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures
    Leibniz Research Alliance INFECTIONS’21
    Germany Center for Infection Research (DZIF), partner site Hannover - Braunschweig
    Technical University)

  • Jan Rupp

    (University Hospital Schleswig-Holstein
    German Center for Infection Research (DZIF), partner site Hamburg - Lübeck - Borstel - Riems)

  • Joerg Steinmann

    (University Medical Center Essen
    Paracelsus Medical Private University, Klinikum Nürnberg)

  • Stefan Niemann

    (Molecular and Experimental Mycobacteriology, Research Center Borstel
    German Center for Infection Research (DZIF), partner site Hamburg - Lübeck - Borstel - Riems
    Leibniz Research Alliance INFECTIONS’21)

  • Thomas A. Kohl

    (Molecular and Experimental Mycobacteriology, Research Center Borstel
    German Center for Infection Research (DZIF), partner site Hamburg - Lübeck - Borstel - Riems)

Abstract

Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.

Suggested Citation

  • Matthias I. Gröschel & Conor J. Meehan & Ivan Barilar & Margo Diricks & Aitor Gonzaga & Matthias Steglich & Oscar Conchillo-Solé & Isabell-Christin Scherer & Uwe Mamat & Christian F. Luz & Katrien Bru, 2020. "The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15123-0
    DOI: 10.1038/s41467-020-15123-0
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