IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-15046-w.html
   My bibliography  Save this article

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Author

Listed:
  • Xiang Shu

    (Vanderbilt University Medical Center)

  • Jirong Long

    (Vanderbilt University Medical Center)

  • Qiuyin Cai

    (Vanderbilt University Medical Center)

  • Sun-Seog Kweon

    (Chonnam National University Medical School
    Chonnam National University Hwasun Hospital)

  • Ji-Yeob Choi

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Cancer Research Institute, Seoul National University College of Medicine)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Sue K. Park

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Cancer Research Institute, Seoul National University College of Medicine)

  • Manjeet K. Bolla

    (University of Cambridge)

  • Joe Dennis

    (University of Cambridge)

  • Qin Wang

    (University of Cambridge)

  • Yaohua Yang

    (Vanderbilt University Medical Center)

  • Jiajun Shi

    (Vanderbilt University Medical Center)

  • Xingyi Guo

    (Vanderbilt University Medical Center)

  • Bingshan Li

    (Vanderbilt Genetics Institute, Vanderbilt University)

  • Ran Tao

    (Vanderbilt University Medical Center
    Vanderbilt Genetics Institute, Vanderbilt University Medical Center)

  • Kristan J. Aronson

    (Queen’s University)

  • Kelvin Y. K. Chan

    (University of Hong Kong
    University of Hong Kong)

  • Tsun L. Chan

    (Hong Kong Hereditary Breast Cancer Family Registry
    Hong Kong Sanatorium & Hospital)

  • Yu-Tang Gao

    (Shanghai Jiaotong University School of Medicine)

  • Mikael Hartman

    (National University Hospital
    Saw Swee Hock School of Public Health, National University of Singapore
    National University of Singapore)

  • Weang Kee Ho

    (University of Nottingham Malaysia Campus)

  • Hidemi Ito

    (Aichi Cancer Center Research Institute
    Nagoya University Graduate School of Medicine)

  • Motoki Iwasaki

    (Division of Epidemiology, Center for Public Health Sciences, National Cancer Center)

  • Hiroji Iwata

    (Aichi Cancer Center)

  • Esther M. John

    (Cancer Prevention Institute of California
    School of Medicine, Stanford University
    Stanford Cancer Institute, Stanford University School of Medicine)

  • Yoshio Kasuga

    (Nagano Matsushiro General Hospital)

  • Ui Soon Khoo

    (University of Hong Kong)

  • Mi-Kyung Kim

    (Division of Cancer Epidemiology and Management, National Cancer Center)

  • Sun-Young Kong

    (National Cancer Center Graduate School of Cancer Science and Policy
    Hospital, National Cancer Center
    Research Institute, National Cancer Center)

  • Allison W. Kurian

    (School of Medicine, Stanford University)

  • Ava Kwong

    (Hong Kong Hereditary Breast Cancer Family Registry
    University of Hong Kong
    Hong Kong Sanatorium & Hospital)

  • Eun-Sook Lee

    (National Cancer Center Graduate School of Cancer Science and Policy
    Hospital, National Cancer Center
    Research Institute, National Cancer Center)

  • Jingmei Li

    (National University of Singapore
    Human Genetics, Genome Institute of Singapore
    Karolinska Institutet)

  • Artitaya Lophatananon

    (Warwick University
    Institute of Population Health, University of Manchester)

  • Siew-Kee Low

    (RIKEN Center for Integrative Medical Sciences)

  • Shivaani Mariapun

    (Cancer Research Malaysia)

  • Koichi Matsuda

    (University of Tokyo)

  • Keitaro Matsuo

    (Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine)

  • Kenneth Muir

    (Warwick University
    Institute of Population Health, University of Manchester)

  • Dong-Young Noh

    (Cancer Research Institute, Seoul National University College of Medicine
    Seoul National University Hospital)

  • Boyoung Park

    (Hanyang University College of Medicine)

  • Min-Ho Park

    (Chonnam National University Medical School)

  • Chen-Yang Shen

    (China Medical University
    Taiwan Biobank, Institute of Biomedical Sciences)

  • Min-Ho Shin

    (Chonnam National University Medical School)

  • John J. Spinelli

    (Population Oncology, BC Cancer
    University of British Columbia)

  • Atsushi Takahashi

    (RIKEN Center for Integrative Medical Sciences
    Research Institute, National Cerebral and Cardiovascular Center)

  • Chiuchen Tseng

    (University of Southern California)

  • Shoichiro Tsugane

    (National Cancer Center)

  • Anna H. Wu

    (University of Southern California)

  • Yong-Bing Xiang

    (Shanghai Jiaotong University School of Medicine)

  • Taiki Yamaji

    (Division of Epidemiology, Center for Public Health Sciences, National Cancer Center)

  • Ying Zheng

    (Shanghai Municipal Center for Disease Control and Prevention)

  • Roger L. Milne

    (Cancer Epidemiology Division, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    Precision Medicine, School of Clinical Sciences at Monash Health, Monash University)

  • Alison M. Dunning

    (University of Cambridge)

  • Paul D. P. Pharoah

    (University of Cambridge
    University of Cambridge)

  • Montserrat García-Closas

    (National Cancer Institute)

  • Soo-Hwang Teo

    (Cancer Research Malaysia
    University Malaya)

  • Xiao-ou Shu

    (Vanderbilt University Medical Center)

  • Daehee Kang

    (Seoul National University College of Medicine
    Cancer Research Institute, Seoul National University College of Medicine
    Seoul National University Graduate School
    Institute of Environmental Medicine, Seoul National University Medical Research Center)

  • Douglas F. Easton

    (University of Cambridge
    University of Cambridge)

  • Jacques Simard

    (Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center)

  • Wei Zheng

    (Vanderbilt University Medical Center)

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P

Suggested Citation

  • Xiang Shu & Jirong Long & Qiuyin Cai & Sun-Seog Kweon & Ji-Yeob Choi & Michiaki Kubo & Sue K. Park & Manjeet K. Bolla & Joe Dennis & Qin Wang & Yaohua Yang & Jiajun Shi & Xingyi Guo & Bingshan Li & Ra, 2020. "Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15046-w
    DOI: 10.1038/s41467-020-15046-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-15046-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-15046-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jie Ping & Guochong Jia & Qiuyin Cai & Xingyi Guo & Ran Tao & Christine Ambrosone & Dezheng Huo & Stefan Ambs & Mollie E. Barnard & Yu Chen & Montserrat Garcia-Closas & Jian Gu & Jennifer J. Hu & Esth, 2024. "Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes," Nature Communications, Nature, vol. 15(1), pages 1-8, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15046-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.