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Dissecting the role of PfAP2-G in malaria gametocytogenesis

Author

Listed:
  • Gabrielle A. Josling

    (The Pennsylvania State University
    The Pennsylvania State University)

  • Timothy J. Russell

    (The Pennsylvania State University
    The Pennsylvania State University)

  • Jarrett Venezia

    (The Pennsylvania State University
    The Pennsylvania State University
    Johns Hopkins University)

  • Lindsey Orchard

    (The Pennsylvania State University
    The Pennsylvania State University)

  • Riëtte Biljon

    (The Pennsylvania State University
    The Pennsylvania State University)

  • Heather J. Painter

    (The Pennsylvania State University
    The Pennsylvania State University
    Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluations and Research, Food and Drug Administration)

  • Manuel Llinás

    (The Pennsylvania State University
    The Pennsylvania State University
    The Pennsylvania State University)

Abstract

In the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to sexual differentiation into gametocytes is essential for transmission to mosquitos. The transcription factor PfAP2-G is a key determinant of sexual commitment that orchestrates this crucial cell fate decision. Here we identify the direct targets of PfAP2-G and demonstrate that it dynamically binds hundreds of sites across the genome. We find that PfAP2-G is a transcriptional activator of early gametocyte genes, and identify differences in PfAP2-G occupancy between gametocytes derived via next-cycle and same-cycle conversion. Our data implicate PfAP2-G not only as a transcriptional activator of gametocyte genes, but also as a potential regulator of genes important for red blood cell invasion. We also find that regulation by PfAP2-G requires interaction with a second transcription factor, PfAP2-I. These results clarify the functional role of PfAP2-G during sexual commitment and early gametocytogenesis.

Suggested Citation

  • Gabrielle A. Josling & Timothy J. Russell & Jarrett Venezia & Lindsey Orchard & Riëtte Biljon & Heather J. Painter & Manuel Llinás, 2020. "Dissecting the role of PfAP2-G in malaria gametocytogenesis," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15026-0
    DOI: 10.1038/s41467-020-15026-0
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    Cited by:

    1. Bing Guo & Victor Borda & Roland Laboulaye & Michele D. Spring & Mariusz Wojnarski & Brian A. Vesely & Joana C. Silva & Norman C. Waters & Timothy D. O’Connor & Shannon Takala-Harrison, 2024. "Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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