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TIGIT limits immune pathology during viral infections

Author

Listed:
  • Michelle Schorer

    (University of Zurich)

  • Nikolas Rakebrandt

    (University of Zurich)

  • Katharina Lambert

    (University of Zurich)

  • Annika Hunziker

    (University of Zurich)

  • Katharina Pallmer

    (Institute of Microbiology, ETH Zurich)

  • Annette Oxenius

    (Institute of Microbiology, ETH Zurich)

  • Anja Kipar

    (University of Zurich)

  • Silke Stertz

    (University of Zurich)

  • Nicole Joller

    (University of Zurich)

Abstract

Co-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and restricting immune pathology. The TIGIT pathway has been implicated in promoting T cell dysfunction in chronic viral infection. Importantly, TIGIT signaling is functionally linked to IL-10 expression, which has an effect on both virus control and maintenance of tissue homeostasis. However, whether TIGIT has a function in viral persistence or limiting tissue pathology is unclear. Here we report that TIGIT modulation effectively alters the phenotype and cytokine profile of T cells during influenza and chronic LCMV infection, but does not affect virus control in vivo. Instead, TIGIT has an important effect in limiting immune pathology in peripheral organs by inducing IL-10. Our data therefore identify a function of TIGIT in limiting immune pathology that is independent of viral clearance.

Suggested Citation

  • Michelle Schorer & Nikolas Rakebrandt & Katharina Lambert & Annika Hunziker & Katharina Pallmer & Annette Oxenius & Anja Kipar & Silke Stertz & Nicole Joller, 2020. "TIGIT limits immune pathology during viral infections," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15025-1
    DOI: 10.1038/s41467-020-15025-1
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    Cited by:

    1. Thomas Liechti & Yaser Iftikhar & Massimo Mangino & Margaret Beddall & Charles W. Goss & Jane A. O’Halloran & Philip A. Mudd & Mario Roederer, 2022. "Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Yoav Charpak-Amikam & Tom Lapidus & Batya Isaacson & Alexandra Duev-Cohen & Tal Levinson & Adi Elbaz & Francesca Levi-Schaffer & Nir Osherov & Gilad Bachrach & Lois L. Hoyer & Maya Korem & Ronen Ben-A, 2022. "Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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