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Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

Author

Listed:
  • Jiaxing Gong

    (Harvard Medical School
    Zhejiang University School of Medicine
    Key Laboratory of Oral Biomedical Research of Zhejiang Province)

  • Carl C. L. Schuurmans

    (Harvard Medical School
    Utrecht University
    Utrecht University)

  • Anne Metje van Genderen

    (Harvard Medical School
    Utrecht University)

  • Xia Cao

    (Harvard Medical School)

  • Wanlu Li

    (Harvard Medical School)

  • Feng Cheng

    (Harvard Medical School)

  • Jacqueline Jialu He

    (Harvard Medical School)

  • Arturo López

    (Harvard Medical School)

  • Valentin Huerta

    (Harvard Medical School)

  • Jennifer Manríquez

    (Harvard Medical School)

  • Ruiquan Li

    (University of Nebraska Medical Center)

  • Hongbin Li

    (Harvard Medical School)

  • Clément Delavaux

    (Harvard Medical School)

  • Shikha Sebastian

    (Harvard Medical School)

  • Pamela E. Capendale

    (Harvard Medical School
    Utrecht University
    Utrecht University)

  • Huiming Wang

    (Zhejiang University School of Medicine
    Key Laboratory of Oral Biomedical Research of Zhejiang Province)

  • Jingwei Xie

    (University of Nebraska Medical Center)

  • Mengfei Yu

    (Zhejiang University School of Medicine
    Key Laboratory of Oral Biomedical Research of Zhejiang Province)

  • Rosalinde Masereeuw

    (Utrecht University)

  • Tina Vermonden

    (Utrecht University)

  • Yu Shrike Zhang

    (Harvard Medical School)

Abstract

Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations.

Suggested Citation

  • Jiaxing Gong & Carl C. L. Schuurmans & Anne Metje van Genderen & Xia Cao & Wanlu Li & Feng Cheng & Jacqueline Jialu He & Arturo López & Valentin Huerta & Jennifer Manríquez & Ruiquan Li & Hongbin Li &, 2020. "Complexation-induced resolution enhancement of 3D-printed hydrogel constructs," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14997-4
    DOI: 10.1038/s41467-020-14997-4
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    Cited by:

    1. Baofu Ding & Pengyuan Zeng & Ziyang Huang & Lixin Dai & Tianshu Lan & Hao Xu & Yikun Pan & Yuting Luo & Qiangmin Yu & Hui-Ming Cheng & Bilu Liu, 2022. "A 2D material–based transparent hydrogel with engineerable interference colours," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Mian Wang & Wanlu Li & Jin Hao & Arthur Gonzales & Zhibo Zhao & Regina Sanchez Flores & Xiao Kuang & Xuan Mu & Terry Ching & Guosheng Tang & Zeyu Luo & Carlos Ezio Garciamendez-Mijares & Jugal Kishore, 2022. "Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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