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Maturation of the human striatal dopamine system revealed by PET and quantitative MRI

Author

Listed:
  • Bart Larsen

    (University of Pittsburgh)

  • Valur Olafsson

    (NUBIC, Northeastern University)

  • Finnegan Calabro

    (University of Pittsburgh
    University of Pittsburgh)

  • Charles Laymon

    (University of Pittsburgh
    University of Pittsburgh)

  • Brenden Tervo-Clemmens

    (University of Pittsburgh)

  • Elizabeth Campbell

    (University of Pittsburgh)

  • Davneet Minhas

    (University of Pittsburgh)

  • David Montez

    (University of Pittsburgh)

  • Julie Price

    (Massachusetts General Hospital, Harvard Medical School)

  • Beatriz Luna

    (University of Pittsburgh)

Abstract

The development of the striatum dopamine (DA) system through human adolescence, a time of increased sensation seeking and vulnerability to the emergence of psychopathology, has been difficult to study due to pediatric restrictions on direct in vivo assessments of DA. Here, we applied neuroimaging in a longitudinal sample of n = 146 participants aged 12–30. R2′, an MR measure of tissue iron which co-localizes with DA vesicles and is necessary for DA synthesis, was assessed across the sample. In the 18–30 year-olds (n = 79) we also performed PET using [11C]dihydrotetrabenazine (DTBZ), a measure of presynaptic vesicular DA storage, and [11C]raclopride (RAC), an indicator of D2/D3 receptor availability. We observed decreases in D2/D3 receptor availability with age, while presynaptic vesicular DA storage (as measured by DTBZ), which was significantly associated with R2′ (standardized coefficient = 0.29, 95% CI = [0.11, 0.48]), was developmentally stable by age 18. Our results provide new evidence for maturational specialization of the striatal DA system through adolescence.

Suggested Citation

  • Bart Larsen & Valur Olafsson & Finnegan Calabro & Charles Laymon & Brenden Tervo-Clemmens & Elizabeth Campbell & Davneet Minhas & David Montez & Julie Price & Beatriz Luna, 2020. "Maturation of the human striatal dopamine system revealed by PET and quantitative MRI," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14693-3
    DOI: 10.1038/s41467-020-14693-3
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    Cited by:

    1. Lauren M. Reynolds & Giovanni Hernandez & Del MacGowan & Christina Popescu & Dominique Nouel & Santiago Cuesta & Samuel Burke & Katherine E. Savell & Janet Zhao & Jose Maria Restrepo-Lozano & Michel G, 2023. "Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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