IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-14594-5.html
   My bibliography  Save this article

Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

Author

Listed:
  • Kavita Y. Sarin

    (Stanford University School of Medicine)

  • Yuan Lin

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, 1050 Wishard Blvd)

  • Roxana Daneshjou

    (Stanford University School of Medicine)

  • Andrey Ziyatdinov

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health)

  • Gudmar Thorleifsson

    (deCODE genetics/Amgen Inc.)

  • Adam Rubin

    (Stanford University School of Medicine)

  • Luba M. Pardo

    (Erasmus University Medical Center)

  • Wenting Wu

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, 1050 Wishard Blvd)

  • Paul A. Khavari

    (Stanford University School of Medicine)

  • Andre Uitterlinden

    (Erasmus University Medical Center)

  • Tamar Nijsten

    (Erasmus University Medical Center)

  • Amanda E. Toland

    (Division of Human Genetics, Comprehensive Cancer Center, Ohio State University)

  • Jon H. Olafsson

    (Landspitali-University Hospital
    University of Iceland)

  • Bardur Sigurgeirsson

    (Landspitali-University Hospital
    University of Iceland)

  • Kristin Thorisdottir

    (Landspitali-University Hospital
    University of Iceland)

  • Eric Jorgensen

    (Kaiser Permanente Northern California)

  • Alice S. Whittemore

    (Stanford University School of Medicine Redwood Bldg)

  • Peter Kraft

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health)

  • Simon N. Stacey

    (deCODE genetics/Amgen Inc.)

  • Kari Stefansson

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Maryam M. Asgari

    (Massachusetts General Hospital)

  • Jiali Han

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, 1050 Wishard Blvd)

Abstract

Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneous SCC. Here, we report the largest cutaneous SCC meta-analysis to date, representing six international cohorts and totaling 19,149 SCC cases and 680,049 controls. We discover eight novel loci associated with SCC, confirm all previously associated loci, and perform fine mapping of causal variants. The novel SNPs occur within skin-specific regulatory elements and implicate loci involved in cancer development, immune regulation, and keratinocyte differentiation in SCC susceptibility.

Suggested Citation

  • Kavita Y. Sarin & Yuan Lin & Roxana Daneshjou & Andrey Ziyatdinov & Gudmar Thorleifsson & Adam Rubin & Luba M. Pardo & Wenting Wu & Paul A. Khavari & Andre Uitterlinden & Tamar Nijsten & Amanda E. Tol, 2020. "Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14594-5
    DOI: 10.1038/s41467-020-14594-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-14594-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-14594-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14594-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.