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Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Author

Listed:
  • Peter J. Vuillermin

    (Deakin University, School of Medicine
    Barwon Health
    The Murdoch Children’s Research Institute)

  • Martin O’Hely

    (Deakin University, School of Medicine
    The Murdoch Children’s Research Institute)

  • Fiona Collier

    (Deakin University, School of Medicine
    Barwon Health
    The Murdoch Children’s Research Institute)

  • Katrina J. Allen

    (The Murdoch Children’s Research Institute
    The Royal Children’s Hospital
    The University of Melbourne)

  • Mimi L. K. Tang

    (The Murdoch Children’s Research Institute
    The Royal Children’s Hospital
    The University of Melbourne)

  • Leonard C. Harrison

    (The University of Melbourne
    Walter and Eliza Hall Institute)

  • John B. Carlin

    (The Murdoch Children’s Research Institute
    The Royal Children’s Hospital
    The University of Melbourne)

  • Richard Saffery

    (The Murdoch Children’s Research Institute
    The University of Melbourne)

  • Sarath Ranganathan

    (The Murdoch Children’s Research Institute
    The Royal Children’s Hospital
    The University of Melbourne)

  • Peter D. Sly

    (The Murdoch Children’s Research Institute
    University of Queensland, South Brisbane)

  • Lawrence Gray

    (Deakin University, School of Medicine
    Barwon Health
    The Murdoch Children’s Research Institute)

  • John Molloy

    (Deakin University, School of Medicine
    Barwon Health
    The Murdoch Children’s Research Institute)

  • Angela Pezic

    (The Murdoch Children’s Research Institute)

  • Michael Conlon

    (Commonwealth Science and Industrial Research Organisation)

  • David Topping

    (Commonwealth Science and Industrial Research Organisation)

  • Karen Nelson

    (J. Craig Venter Institute)

  • Charles R. Mackay

    (Monash University)

  • Laurence Macia

    (University of Sydney, Charles Perkins Centre)

  • Jennifer Koplin

    (The Murdoch Children’s Research Institute
    The University of Melbourne)

  • Samantha L. Dawson

    (Deakin University, School of Medicine
    The Murdoch Children’s Research Institute)

  • Margarita Moreno-Betancur

    (The Murdoch Children’s Research Institute
    The University of Melbourne)

  • Anne-Louise Ponsonby

    (The Murdoch Children’s Research Institute
    The University of Melbourne)

Abstract

In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.

Suggested Citation

  • Peter J. Vuillermin & Martin O’Hely & Fiona Collier & Katrina J. Allen & Mimi L. K. Tang & Leonard C. Harrison & John B. Carlin & Richard Saffery & Sarath Ranganathan & Peter D. Sly & Lawrence Gray & , 2020. "Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14552-1
    DOI: 10.1038/s41467-020-14552-1
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    Cited by:

    1. Tomás Clive Barker-Tejeda & Elisa Zubeldia-Varela & Andrea Macías-Camero & Lola Alonso & Isabel Adoración Martín-Antoniano & María Fernanda Rey-Stolle & Leticia Mera-Berriatua & Raphaëlle Bazire & Pau, 2024. "Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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