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Non-invasive recording from the human olfactory bulb

Author

Listed:
  • Behzad Iravani

    (Karolinska Institutet)

  • Artin Arshamian

    (Karolinska Institutet
    Stockholm University)

  • Kathrin Ohla

    (Cognitive Neuroscience
    Monell Chemical Senses Center)

  • Donald A. Wilson

    (Nathan Kline Institute for Psychiatric Research
    New York University Langone Medical School)

  • Johan N. Lundström

    (Karolinska Institutet
    Monell Chemical Senses Center
    University of Pennsylvania
    Stockholm University Brain Imaging Centre, Stockholm University)

Abstract

Current non-invasive neuroimaging methods can assess neural activity in all areas of the human brain but the olfactory bulb (OB). The OB has been suggested to fulfill a role comparable to that of V1 and the thalamus in the visual system and have been closely linked to a wide range of olfactory tasks and neuropathologies. Here we present a method for non-invasive recording of signals from the human OB with millisecond precision. We demonstrate that signals obtained via recordings from EEG electrodes at the nasal bridge represent responses from the human olfactory bulb - recordings we term Electrobulbogram (EBG). The EBG will aid future olfactory-related translational work but can also potentially be implemented as an everyday clinical tool to detect pathology-related changes in human central olfactory processing in neurodegenerative diseases. In conclusion, the EBG is localized to the OB, is reliable, and follows response patterns demonstrated in non-human animal models.

Suggested Citation

  • Behzad Iravani & Artin Arshamian & Kathrin Ohla & Donald A. Wilson & Johan N. Lundström, 2020. "Non-invasive recording from the human olfactory bulb," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14520-9
    DOI: 10.1038/s41467-020-14520-9
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