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Abundance and diversity of resistomes differ between healthy human oral cavities and gut

Author

Listed:
  • Victoria R. Carr

    (Oral and Craniofacial Sciences, King’s College London)

  • Elizabeth A. Witherden

    (Oral and Craniofacial Sciences, King’s College London)

  • Sunjae Lee

    (Oral and Craniofacial Sciences, King’s College London)

  • Saeed Shoaie

    (Oral and Craniofacial Sciences, King’s College London
    KTH—Royal Institute of Technology)

  • Peter Mullany

    (University College London)

  • Gordon B. Proctor

    (Oral and Craniofacial Sciences, King’s College London)

  • David Gomez-Cabrero

    (Oral and Craniofacial Sciences, King’s College London
    Departamento de Salud-Universidad Pública de Navarra, Pamplona
    Karolinska Institutet (L8:05). Karolinska University Hospital)

  • David L. Moyes

    (Oral and Craniofacial Sciences, King’s College London)

Abstract

The global threat of antimicrobial resistance has driven the use of high-throughput sequencing techniques to monitor the profile of resistance genes, known as the resistome, in microbial populations. The human oral cavity contains a poorly explored reservoir of these genes. Here we analyse and compare the resistome profiles of 788 oral cavities worldwide with paired stool metagenomes. We find country and body site-specific differences in the prevalence of antimicrobial resistance genes, classes and mechanisms in oral and stool samples. Within individuals, the highest abundances of antimicrobial resistance genes are found in the oral cavity, but the oral cavity contains a lower diversity of resistance genes compared to the gut. Additionally, co-occurrence analysis shows contrasting ARG-species associations between saliva and stool samples. Maintenance and persistence of antimicrobial resistance is likely to vary across different body sites. Thus, we highlight the importance of characterising the resistome across body sites to uncover the antimicrobial resistance potential in the human body.

Suggested Citation

  • Victoria R. Carr & Elizabeth A. Witherden & Sunjae Lee & Saeed Shoaie & Peter Mullany & Gordon B. Proctor & David Gomez-Cabrero & David L. Moyes, 2020. "Abundance and diversity of resistomes differ between healthy human oral cavities and gut," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14422-w
    DOI: 10.1038/s41467-020-14422-w
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    Cited by:

    1. Lucinda J. Bessa & João Botelho & Vanessa Machado & Ricardo Alves & José João Mendes, 2022. "Managing Oral Health in the Context of Antimicrobial Resistance," IJERPH, MDPI, vol. 19(24), pages 1-17, December.
    2. Carlos M. Ardila & Annie Marcela Vivares-Builes, 2022. "Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review," IJERPH, MDPI, vol. 19(23), pages 1-10, November.

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