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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Author

Listed:
  • Nikos Papadimitriou

    (International Agency for Research on Cancer)

  • Niki Dimou

    (International Agency for Research on Cancer)

  • Konstantinos K. Tsilidis

    (University of Ioannina School of Medicine
    Imperial College London)

  • Barbara Banbury

    (Fred Hutchinson Cancer Research Center)

  • Richard M. Martin

    (Bristol Medical School, University of Bristol
    University of Bristol
    University Hospitals Bristol NHS Foundation Trust and the University of Bristol)

  • Sarah J. Lewis

    (University of Bristol)

  • Nabila Kazmi

    (Bristol Medical School, University of Bristol)

  • Timothy M. Robinson

    (University of Bristol)

  • Demetrius Albanes

    (National Institutes of Health)

  • Krasimira Aleksandrova

    (Arthur-Scheunert-Allee 114-116)

  • Sonja I. Berndt

    (National Institutes of Health)

  • D. Timothy Bishop

    (University of Leeds)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
    German Cancer Research Center (DKFZ))

  • Daniel D. Buchanan

    (The University of Melbourne
    The University of Melbourne
    The Royal Melbourne Hospital)

  • Bas Bueno-de-Mesquita

    (National Institute for Public Health and the Environment (RIVM), PO Box 1
    University Medical Centre
    The School of Public Health, Imperial College London, St Mary’s Campus, Norfolk Place, London
    University of Malaya, Pantai Valley)

  • Peter T. Campbell

    (American Cancer Society)

  • Sergi Castellví-Bel

    (University of Barcelona)

  • Andrew T. Chan

    (Massachusetts General Hospital and Harvard Medical School
    Massachusetts General Hospital and Harvard Medical School)

  • Jenny Chang-Claude

    (German Cancer Research Center (DKFZ)
    University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH))

  • Merete Ellingjord-Dale

    (Imperial College London)

  • Jane C. Figueiredo

    (Cedars-Sinai Medical Center
    University of Southern California)

  • Steven J. Gallinger

    (University of Toronto)

  • Graham G. Giles

    (The University of Melbourne
    Cancer Council Victoria)

  • Edward Giovannucci

    (Harvard University
    T.H. H, Chan School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School)

  • Stephen B. Gruber

    (University of Southern California)

  • Andrea Gsur

    (Medical University Vienna)

  • Jochen Hampe

    (University Hospital Dresden, Technische Universität Dresden (TU Dresden))

  • Heather Hampel

    (The Ohio State University Comprehensive Cancer Center)

  • Sophia Harlid

    (Oncology, Umea University)

  • Tabitha A. Harrison

    (Fred Hutchinson Cancer Research Center)

  • Michael Hoffmeister

    (German Cancer Research Center (DKFZ))

  • John L. Hopper

    (The University of Melbourne
    Seoul National University)

  • Li Hsu

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • José María Huerta

    (CIBER de Epidemiología y Salud Pública (CIBERESP)
    Murcia Regional Health Council, IMIB-Arrixaca)

  • Jeroen R. Huyghe

    (Fred Hutchinson Cancer Research Center)

  • Mark A. Jenkins

    (The University of Melbourne)

  • Temitope O. Keku

    (University of North Carolina)

  • Tilman Kühn

    (German Cancer Research Center (DKFZ))

  • Carlo Vecchia

    (Hellenic Health Foundation
    Università degli Studi di Milano)

  • Loic Marchand

    (University of Hawaii Cancer Center)

  • Christopher I. Li

    (Fred Hutchinson Cancer Research Center)

  • Li Li

    (University of Virginia)

  • Annika Lindblom

    (Karolinska University Hospital
    Karolinska Institutet)

  • Noralane M. Lindor

    (Mayo Clinic)

  • Brigid Lynch

    (The University of Melbourne
    Cancer Council Victoria
    Physical Activity Laboratory, Baker Heart and Diabetes Institute)

  • Sanford D. Markowitz

    (Case Western Reserve University, and University Hospitals of Cleveland)

  • Giovanna Masala

    (Institute for Cancer Research, Prevention and Clinical Network - ISPRO)

  • Anne M. May

    (University Medical Center Utrecht, Utrecht University, P.O. Box 85500)

  • Roger Milne

    (The University of Melbourne
    Cancer Council Victoria
    The University of Melbourne)

  • Evelyn Monninkhof

    (University Medical Center Utrecht, Utrecht University, P.O. Box 85500)

  • Lorena Moreno

    (University of Barcelona)

  • Victor Moreno

    (CIBER de Epidemiología y Salud Pública (CIBERESP)
    Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
    University of Barcelona)

  • Polly A. Newcomb

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Kenneth Offit

    (Memorial Sloan-Kettering Cancer Center
    Weill Cornell Medical College)

  • Vittorio Perduca

    (CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay
    Gustave Roussy
    Université Paris Descartes)

  • Paul D. P. Pharoah

    (University of Cambridge)

  • Elizabeth A. Platz

    (Johns Hopkins Bloomberg School of Public Health)

  • John D. Potter

    (Fred Hutchinson Cancer Research Center)

  • Gad Rennert

    (Lady Davis Carmel Medical Center
    Technion-Israel Institute of Technology
    Clalit National Cancer Control Center)

  • Elio Riboli

    (Imperial College London)

  • Maria-Jose Sánchez

    (CIBER de Epidemiología y Salud Pública (CIBERESP)
    University of Granada)

  • Stephanie L. Schmit

    (University of Southern California
    H. Lee Moffitt Cancer Center and Research Institute)

  • Robert E. Schoen

    (University of Pittsburgh Medical Center)

  • Gianluca Severi

    (CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay
    Gustave Roussy)

  • Sabina Sieri

    (Fondazione IRCCS Istituto Nazionale dei Tumori)

  • Martha L. Slattery

    (University of Utah)

  • Mingyang Song

    (Massachusetts General Hospital and Harvard Medical School
    Massachusetts General Hospital and Harvard Medical School
    Harvard University
    T.H. H, Chan School of Public Health)

  • Catherine M. Tangen

    (Fred Hutchinson Cancer Research Center)

  • Stephen N. Thibodeau

    (Mayo Clinic)

  • Ruth C. Travis

    (University of Oxford)

  • Antonia Trichopoulou

    (Hellenic Health Foundation)

  • Cornelia M. Ulrich

    (University of Utah)

  • Franzel J. B. Duijnhoven

    (Wageningen University and Research)

  • Bethany Guelpen

    (Umeå University
    Umeå University)

  • Pavel Vodicka

    (Institute of Experimental Medicine of the Czech Academy of Sciences
    Charles University
    Charles University)

  • Emily White

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Alicja Wolk

    (Karolinska Institutet)

  • Michael O. Woods

    (Discipline of Genetics)

  • Anna H. Wu

    (University of Southern California, Preventative Medicine)

  • Ulrike Peters

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Marc J. Gunter

    (International Agency for Research on Cancer)

  • Neil Murphy

    (International Agency for Research on Cancer)

Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

Suggested Citation

  • Nikos Papadimitriou & Niki Dimou & Konstantinos K. Tsilidis & Barbara Banbury & Richard M. Martin & Sarah J. Lewis & Nabila Kazmi & Timothy M. Robinson & Demetrius Albanes & Krasimira Aleksandrova & S, 2020. "Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14389-8
    DOI: 10.1038/s41467-020-14389-8
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