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Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia

Author

Listed:
  • Franc Llorens

    (University Medical Center Göttingen
    Network center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of Health
    Hospitalet de Llobregat)

  • Peter Hermann

    (University Medical Center Göttingen)

  • Anna Villar-Piqué

    (University Medical Center Göttingen)

  • Daniela Diaz-Lucena

    (Network center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of Health)

  • Katarina Nägga

    (Linköping University)

  • Oskar Hansson

    (Memory Clinic, Skåne University Hospital
    Lund University)

  • Isabel Santana

    (University of Coimbra)

  • Matthias Schmitz

    (University Medical Center Göttingen
    German Center for Neurodegenerative Diseases (DZNE))

  • Christian Schmidt

    (University Medical Center Göttingen
    Center for Head- and Neuro-Medicine, Klinikum Kassel)

  • Daniela Varges

    (University Medical Center Göttingen)

  • Stefan Goebel

    (University Medical Center Göttingen)

  • Julien Dumurgier

    (Center of Cognitive Neurology and Inserm U942 Lariboisière Hospital AP-HP University Paris Diderot)

  • Henrik Zetterberg

    (University College London
    UK Dementia Research Institute at UCL
    Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital
    The Sahlgrenska Academy at the University of Gothenburg)

  • Kaj Blennow

    (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital
    The Sahlgrenska Academy at the University of Gothenburg)

  • Claire Paquet

    (Center of Cognitive Neurology and Inserm U942 Lariboisière Hospital AP-HP University Paris Diderot)

  • Inês Baldeiras

    (University of Coimbra)

  • Isidro Ferrer

    (Network center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of Health
    Hospitalet de Llobregat
    University of Barcelona
    University of Barcelona)

  • Inga Zerr

    (University Medical Center Göttingen
    German Center for Neurodegenerative Diseases (DZNE))

Abstract

The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer’s disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias.

Suggested Citation

  • Franc Llorens & Peter Hermann & Anna Villar-Piqué & Daniela Diaz-Lucena & Katarina Nägga & Oskar Hansson & Isabel Santana & Matthias Schmitz & Christian Schmidt & Daniela Varges & Stefan Goebel & Juli, 2020. "Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14373-2
    DOI: 10.1038/s41467-020-14373-2
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