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A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease

Author

Listed:
  • Qingcai Liu

    (China Agricultural University)

  • Suining Deng

    (China Agricultural University)

  • Baoshen Liu

    (Shandong Agricultural University)

  • Yongfu Tao

    (China Agricultural University)

  • Haiyue Ai

    (China Agricultural University)

  • Jianju Liu

    (China Agricultural University)

  • Yongzhong Zhang

    (Shandong Agricultural University)

  • Yan Zhao

    (Shandong Agricultural University)

  • Mingliang Xu

    (China Agricultural University)

Abstract

Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibitor alpha (RabGDIα) is the host susceptibility factor for RBSDV. The viral P7-1 protein binds tightly to the exon-10 and C-terminal regions of RabGDIα to recruit it for viral infection. Insertion of a helitron transposon into RabGDIα intron 10 creates alternative splicing to replace the wild-type exon 10 with a helitron-derived exon 10. The resultant splicing variant RabGDIα-hel has difficulty being recruited by P7-1, thus leading to quantitative recessive resistance to MRDD. All naturally occurring resistance alleles may have arisen from a recent single helitron insertion event. These resistance alleles are valuable to improve maize resistance to MRDD and potentially to engineer RBSDV resistance in other crops.

Suggested Citation

  • Qingcai Liu & Suining Deng & Baoshen Liu & Yongfu Tao & Haiyue Ai & Jianju Liu & Yongzhong Zhang & Yan Zhao & Mingliang Xu, 2020. "A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14372-3
    DOI: 10.1038/s41467-020-14372-3
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    Cited by:

    1. Gengshen Chen & Bao Zhang & Junqiang Ding & Hongze Wang & Ce Deng & Jiali Wang & Qianhui Yang & Qianyu Pi & Ruyang Zhang & Haoyu Zhai & Junfei Dong & Junshi Huang & Jiabao Hou & Junhua Wu & Jiamin Que, 2022. "Cloning southern corn rust resistant gene RppK and its cognate gene AvrRppK from Puccinia polysora," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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