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Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice

Author

Listed:
  • Kelly E. R. Bachta

    (Northwestern University, Feinberg School of Medicine
    Northwestern University, Feinberg School of Medicine)

  • Jonathan P. Allen

    (Northwestern University, Feinberg School of Medicine
    Loyola University Chicago, Stritch School of Medicine)

  • Bettina H. Cheung

    (Northwestern University, Feinberg School of Medicine)

  • Cheng-Hsun Chiu

    (Chang Gung University College of Medicine)

  • Alan R. Hauser

    (Northwestern University, Feinberg School of Medicine
    Northwestern University, Feinberg School of Medicine)

Abstract

Health care-associated infections such as Pseudomonas aeruginosa bacteremia pose a major clinical risk for hospitalized patients. However, these systemic infections are presumed to be a “dead-end” for P. aeruginosa and to have no impact on transmission. Here, we use a mouse infection model to show that P. aeruginosa can spread from the bloodstream to the gallbladder, where it replicates to extremely high numbers. Bacteria in the gallbladder can then seed the intestines and feces, leading to transmission to uninfected cage-mate mice. Our work shows that the gallbladder is crucial for spread of P. aeruginosa from the bloodstream to the feces during bacteremia, a process that promotes transmission in this experimental system. Further research is needed to test to what extent these findings are relevant to infections in patients.

Suggested Citation

  • Kelly E. R. Bachta & Jonathan P. Allen & Bettina H. Cheung & Cheng-Hsun Chiu & Alan R. Hauser, 2020. "Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14363-4
    DOI: 10.1038/s41467-020-14363-4
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    Cited by:

    1. Caitlyn L. Holmes & Katherine G. Dailey & Karthik Hullahalli & Alexis E. Wilcox & Sophia Mason & Bridget S. Moricz & Lavinia V. Unverdorben & George I. Balazs & Matthew K. Waldor & Michael A. Bachman, 2025. "Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung," Nature Communications, Nature, vol. 16(1), pages 1-13, December.

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