IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-14336-7.html
   My bibliography  Save this article

Decorating bacteria with self-assembled synthetic receptors

Author

Listed:
  • Naama Lahav-Mankovski

    (Weizmann Institute of Science)

  • Pragati Kishore Prasad

    (Weizmann Institute of Science)

  • Noa Oppenheimer-Low

    (Weizmann Institute of Science)

  • Gal Raviv

    (Weizmann Institute of Science)

  • Tali Dadosh

    (Weizmann Institute of Science)

  • Tamar Unger

    (Weizmann Institute of Science)

  • Tomer Meir Salame

    (Weizmann Institute of Science)

  • Leila Motiei

    (Weizmann Institute of Science)

  • David Margulies

    (Weizmann Institute of Science)

Abstract

The responses of cells to their surroundings are mediated by the binding of cell surface proteins (CSPs) to extracellular signals. Such processes are regulated via dynamic changes in the structure, composition, and expression levels of CSPs. In this study, we demonstrate the possibility of decorating bacteria with artificial, self-assembled receptors that imitate the dynamic features of CSPs. We show that the local concentration of these receptors on the bacterial membrane and their structure can be reversibly controlled using suitable chemical signals, in a way that resembles changes that occur with CSP expression levels or posttranslational modifications (PTMs), respectively. We also show that these modifications can endow the bacteria with programmable properties, akin to the way CSP responses can induce cellular functions. By programming the bacteria to glow, adhere to surfaces, or interact with proteins or mammalian cells, we demonstrate the potential to tailor such biomimetic systems for specific applications.

Suggested Citation

  • Naama Lahav-Mankovski & Pragati Kishore Prasad & Noa Oppenheimer-Low & Gal Raviv & Tali Dadosh & Tamar Unger & Tomer Meir Salame & Leila Motiei & David Margulies, 2020. "Decorating bacteria with self-assembled synthetic receptors," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14336-7
    DOI: 10.1038/s41467-020-14336-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-14336-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-14336-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yu-Hsuan Yeh & Vince W. Kelly & Rahman Rahman Pour & Shannon J. Sirk, 2024. "A molecular toolkit for heterologous protein secretion across Bacteroides species," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14336-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.