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Tracking regional brain growth up to age 13 in children born term and very preterm

Author

Listed:
  • Deanne K. Thompson

    (Murdoch Children’s Research Institute
    Murdoch Children’s Research Institute
    University of Melbourne
    Florey Institute of Neuroscience and Mental Health)

  • Lillian G. Matthews

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Bonnie Alexander

    (Murdoch Children’s Research Institute
    Murdoch Children’s Research Institute)

  • Katherine J. Lee

    (Murdoch Children’s Research Institute
    University of Melbourne
    Murdoch Children’s Research Institute)

  • Claire E. Kelly

    (Murdoch Children’s Research Institute
    Murdoch Children’s Research Institute)

  • Chris L. Adamson

    (Murdoch Children’s Research Institute)

  • Rod W. Hunt

    (Murdoch Children’s Research Institute
    University of Melbourne
    Royal Children’s Hospital)

  • Jeanie L. Y. Cheong

    (Murdoch Children’s Research Institute
    Royal Women’s Hospital
    University of Melbourne)

  • Megan Spencer-Smith

    (Murdoch Children’s Research Institute
    Monash University)

  • Jeffrey J. Neil

    (Washington University School of Medicine)

  • Marc L. Seal

    (Murdoch Children’s Research Institute
    University of Melbourne)

  • Terrie E. Inder

    (Murdoch Children’s Research Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Lex W. Doyle

    (Murdoch Children’s Research Institute
    University of Melbourne
    Royal Women’s Hospital
    University of Melbourne)

  • Peter J. Anderson

    (Murdoch Children’s Research Institute
    Monash University)

Abstract

Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.

Suggested Citation

  • Deanne K. Thompson & Lillian G. Matthews & Bonnie Alexander & Katherine J. Lee & Claire E. Kelly & Chris L. Adamson & Rod W. Hunt & Jeanie L. Y. Cheong & Megan Spencer-Smith & Jeffrey J. Neil & Marc L, 2020. "Tracking regional brain growth up to age 13 in children born term and very preterm," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14334-9
    DOI: 10.1038/s41467-020-14334-9
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