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Comprehensive T cell repertoire characterization of non-small cell lung cancer

Author

Listed:
  • Alexandre Reuben

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Jiexin Zhang

    (The University of Texas MD Anderson Cancer Center)

  • Shin-Heng Chiou

    (Institute for Immunity, Transplantation, and Infection Operations, Howard Hughes Medical Institute)

  • Rachel M. Gittelman

    (Adaptive Biotechnologies)

  • Jun Li

    (The University of Texas MD Anderson Cancer Center)

  • Won-Chul Lee

    (The University of Texas MD Anderson Cancer Center)

  • Junya Fujimoto

    (The University of Texas MD Anderson Cancer Center)

  • Carmen Behrens

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Xiaoke Liu

    (The University of Texas MD Anderson Cancer Center)

  • Feng Wang

    (The University of Texas MD Anderson Cancer Center)

  • Kelly Quek

    (The University of Texas MD Anderson Cancer Center)

  • Chunlin Wang

    (iRepertoire, Inc.)

  • Farrah Kheradmand

    (Baylor College of Medicine)

  • Runzhe Chen

    (The University of Texas MD Anderson Cancer Center)

  • Chi-Wan Chow

    (The University of Texas MD Anderson Cancer Center)

  • Heather Lin

    (The University of Texas MD Anderson Cancer Center)

  • Chantale Bernatchez

    (The University of Texas MD Anderson Cancer Center)

  • Ali Jalali

    (The University of Texas MD Anderson Cancer Center)

  • Xin Hu

    (The University of Texas MD Anderson Cancer Center)

  • Chang-Jiun Wu

    (The University of Texas MD Anderson Cancer Center)

  • Agda Karina Eterovic

    (The University of Texas MD Anderson Cancer Center)

  • Edwin Roger Parra

    (The University of Texas MD Anderson Cancer Center)

  • Erik Yusko

    (Adaptive Biotechnologies)

  • Ryan Emerson

    (Adaptive Biotechnologies)

  • Sharon Benzeno

    (Adaptive Biotechnologies)

  • Marissa Vignali

    (Adaptive Biotechnologies)

  • Xifeng Wu

    (The University of Texas MD Anderson Cancer Center)

  • Yuanqing Ye

    (The University of Texas MD Anderson Cancer Center)

  • Latasha D. Little

    (The University of Texas MD Anderson Cancer Center)

  • Curtis Gumbs

    (The University of Texas MD Anderson Cancer Center)

  • Xizeng Mao

    (The University of Texas MD Anderson Cancer Center)

  • Xingzhi Song

    (The University of Texas MD Anderson Cancer Center)

  • Samantha Tippen

    (The University of Texas MD Anderson Cancer Center)

  • Rebecca L. Thornton

    (The University of Texas MD Anderson Cancer Center)

  • Tina Cascone

    (The University of Texas MD Anderson Cancer Center)

  • Alexandra Snyder

    (Adaptive Biotechnologies)

  • Jennifer A. Wargo

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Roy Herbst

    (333 Cedar Street, Yale Cancer Center)

  • Stephen Swisher

    (The University of Texas MD Anderson Cancer Center)

  • Humam Kadara

    (The University of Texas MD Anderson Cancer Center)

  • Cesar Moran

    (The University of Texas MD Anderson Cancer Center)

  • Neda Kalhor

    (The University of Texas MD Anderson Cancer Center)

  • Jianhua Zhang

    (The University of Texas MD Anderson Cancer Center)

  • Paul Scheet

    (The University of Texas MD Anderson Cancer Center)

  • Ara A. Vaporciyan

    (The University of Texas MD Anderson Cancer Center)

  • Boris Sepesi

    (The University of Texas MD Anderson Cancer Center)

  • Don L. Gibbons

    (The University of Texas MD Anderson Cancer Center)

  • Harlan Robins

    (Adaptive Biotechnologies
    Computational Biology Program, Fred Hutchinson Cancer Research Center)

  • Patrick Hwu

    (The University of Texas MD Anderson Cancer Center)

  • John V. Heymach

    (The University of Texas MD Anderson Cancer Center)

  • Padmanee Sharma

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • James P. Allison

    (The University of Texas MD Anderson Cancer Center)

  • Veera Baladandayuthapani

    (The University of Texas MD Anderson Cancer Center)

  • Jack J. Lee

    (The University of Texas MD Anderson Cancer Center)

  • Mark M. Davis

    (Howard Hughes Medical Institute, Stanford)

  • Ignacio I. Wistuba

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • P. Andrew Futreal

    (The University of Texas MD Anderson Cancer Center)

  • Jianjun Zhang

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

Abstract

Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoire attributes are associated with clinicopathologic features, mutational and immune landscape. A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent lung, suggesting a less tumor-focused T cell response, exhibit inferior survival. These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy.

Suggested Citation

  • Alexandre Reuben & Jiexin Zhang & Shin-Heng Chiou & Rachel M. Gittelman & Jun Li & Won-Chul Lee & Junya Fujimoto & Carmen Behrens & Xiaoke Liu & Feng Wang & Kelly Quek & Chunlin Wang & Farrah Kheradma, 2020. "Comprehensive T cell repertoire characterization of non-small cell lung cancer," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14273-0
    DOI: 10.1038/s41467-019-14273-0
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