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Alloying design of biodegradable zinc as promising bone implants for load-bearing applications

Author

Listed:
  • Hongtao Yang

    (Peking University)

  • Bo Jia

    (Shanghai Jiaotong University School of Medicine)

  • Zechuan Zhang

    (Peking University)

  • Xinhua Qu

    (Shanghai Jiaotong University School of Medicine)

  • Guannan Li

    (Peking University)

  • Wenjiao Lin

    (Lifetech Scientific (Shenzhen) Co Ltd)

  • Donghui Zhu

    (Stony Brook University)

  • Kerong Dai

    (Shanghai Jiaotong University School of Medicine)

  • Yufeng Zheng

    (Peking University
    Kumamoto University)

Abstract

Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than biodegradable polymers, yet their strength is roughly less than 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro and in vivo studies. Li exhibits the most effective strengthening role in Zn, followed by Mg. Alloying leads to accelerated degradation, but adequate mechanical integrity can be expected for Zn alloys when considering bone fracture healing. Adding elements Mg, Ca, Sr and Li into Zn can improve the cytocompatibility, osteogenesis, and osseointegration. Further optimization of the ternary Zn-Li alloy system results in Zn-0.8Li-0.4Mg alloy with the ultimate tensile strength 646.69 ± 12.79 MPa and Zn-0.8Li-0.8Mn alloy with elongation 103.27 ± 20%. In summary, biocompatible Zn-based BMs with strength close to pure Ti are promising candidates in orthopedics for load-bearing applications.

Suggested Citation

  • Hongtao Yang & Bo Jia & Zechuan Zhang & Xinhua Qu & Guannan Li & Wenjiao Lin & Donghui Zhu & Kerong Dai & Yufeng Zheng, 2020. "Alloying design of biodegradable zinc as promising bone implants for load-bearing applications," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14153-7
    DOI: 10.1038/s41467-019-14153-7
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    Cited by:

    1. Lile Squires & Ethan Roberts & Amit Bandyopadhyay, 2023. "Radial bimetallic structures via wire arc directed energy deposition-based additive manufacturing," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Bo Peng & Ye Wei & Yu Qin & Jiabao Dai & Yue Li & Aobo Liu & Yun Tian & Liuliu Han & Yufeng Zheng & Peng Wen, 2023. "Machine learning-enabled constrained multi-objective design of architected materials," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Shuang Li & Hongtao Yang & Xinhua Qu & Yu Qin & Aobo Liu & Guo Bao & He Huang & Chaoyang Sun & Jiabao Dai & Junlong Tan & Jiahui Shi & Yan Guan & Wei Pan & Xuenan Gu & Bo Jia & Peng Wen & Xiaogang Wan, 2024. "Multiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Wei Chen & Antoine Hilhorst & Georgios Bokas & Stéphane Gorsse & Pascal J. Jacques & Geoffroy Hautier, 2023. "A map of single-phase high-entropy alloys," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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