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Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent

Author

Listed:
  • Xin Zeng

    (Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital
    Nanjing Medical University)

  • Jie Sun

    (Nanjing Medical University)

  • Suping Li

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China
    University of Chinese Academy of Sciences)

  • Jiyun Shi

    (Chinese Academy of Sciences)

  • Han Gao

    (Beihang University)

  • Wei Sun Leong

    (Massachusetts Institute of Technology)

  • Yiqi Wu

    (Nanjing Medical University)

  • Minghui Li

    (Nanjing Medical University)

  • Chengxin Liu

    (Nanjing Medical University)

  • Ping Li

    (Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital)

  • Jing Kong

    (Massachusetts Institute of Technology)

  • Yi-Zhou Wu

    (Nanjing Medical University)

  • Guangjun Nie

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China
    University of Chinese Academy of Sciences
    The University of Queensland)

  • Yuming Fu

    (Beihang University
    Beihang University)

  • Gen Zhang

    (Nanjing Medical University)

Abstract

Since the discovery of metal nanoparticles (NPs) in the 1960s, unknown toxicity, cost and the ethical hurdles of research in humans have hindered the translation of these NPs to clinical use. In this work, we demonstrate that Pt NPs with protein coronas are generated in vivo in human blood when a patient is treated with cisplatin. These self-assembled Pt NPs form rapidly, accumulate in tumors, and remain in the body for an extended period of time. Additionally, the Pt NPs are safe for use in humans and can act as anti-cancer agents to inhibit chemotherapy-resistant tumor growth by consuming intracellular glutathione and activating apoptosis. The tumor inhibitory activity is greatly amplified when the Pt NPs are loaded in vitro with the chemotherapeutic drug, daunorubicin, and the formulation is effective even in daunorubicin-resistant models. These in vivo-generated metal NPs represent a biocompatible drug delivery platform for chemotherapy resistant tumor treatment.

Suggested Citation

  • Xin Zeng & Jie Sun & Suping Li & Jiyun Shi & Han Gao & Wei Sun Leong & Yiqi Wu & Minghui Li & Chengxin Liu & Ping Li & Jing Kong & Yi-Zhou Wu & Guangjun Nie & Yuming Fu & Gen Zhang, 2020. "Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14131-z
    DOI: 10.1038/s41467-019-14131-z
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    Cited by:

    1. Fangyuan Li & Heng Sun & Jiafeng Ren & Bo Zhang & Xi Hu & Chunyan Fang & Jiyoung Lee & Hongzhou Gu & Daishun Ling, 2022. "A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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