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An electrochemical biosensor for the detection of epithelial-mesenchymal transition

Author

Listed:
  • Xin Du

    (Shandong Normal University)

  • Zhenhua Zhang

    (Shandong Normal University)

  • Xiaodi Zheng

    (Shandong Normal University)

  • Hongyan Zhang

    (Shandong Normal University)

  • Dan Dong

    (Shandong Normal University)

  • Zhenguo Zhang

    (Shandong Normal University)

  • Min Liu

    (Shandong Normal University)

  • Jun Zhou

    (Shandong Normal University
    Nankai University)

Abstract

Epithelial-mesenchymal transition (EMT) is critically involved in a variety of biological processes. Electrochemical sensing offers potential to develop more effective technology for EMT detection. In this study, by using the unique performance of quantum dot (QD)-nanocomposite materials, we establish an electrochemical biosensor that can specifically detect the change of E-cadherin and analyze different stages of EMT. The signal for EMT is largely magnified due to the transmission of molecular information to the electronic device. In addition, differential pulse voltammetry reveals that the response of the electrochemical signals is rapid and sensitive, due to the synergistic effect of QDs and carbon nanotube-gold nanoparticles. Our study thus suggests that electrochemical sensing is an effective technology for detecting EMT and may have broad applications in analyzing various cell type transitions.

Suggested Citation

  • Xin Du & Zhenhua Zhang & Xiaodi Zheng & Hongyan Zhang & Dan Dong & Zhenguo Zhang & Min Liu & Jun Zhou, 2020. "An electrochemical biosensor for the detection of epithelial-mesenchymal transition," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14037-w
    DOI: 10.1038/s41467-019-14037-w
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