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Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Author

Listed:
  • Murugan Subbiah

    (Washington State University)

  • Mark A. Caudell

    (Washington State University
    Food and Agriculture Organization of the United Nations)

  • Colette Mair

    (University of Glasgow)

  • Margaret A. Davis

    (Washington State University)

  • Louise Matthews

    (University of Glasgow)

  • Robert J. Quinlan

    (Washington State University
    Washington State University)

  • Marsha B. Quinlan

    (Washington State University
    Washington State University)

  • Beatus Lyimo

    (Nelson Mandela African Institution of Science and Technology)

  • Joram Buza

    (Nelson Mandela African Institution of Science and Technology)

  • Julius Keyyu

    (Tanzania Wildlife Research Institute)

  • Douglas R. Call

    (Washington State University
    Nelson Mandela African Institution of Science and Technology)

Abstract

Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.

Suggested Citation

  • Murugan Subbiah & Mark A. Caudell & Colette Mair & Margaret A. Davis & Louise Matthews & Robert J. Quinlan & Marsha B. Quinlan & Beatus Lyimo & Joram Buza & Julius Keyyu & Douglas R. Call, 2020. "Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13995-5
    DOI: 10.1038/s41467-019-13995-5
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    Cited by:

    1. Zi-Teng Liu & Rui-Ao Ma & Dong Zhu & Konstantinos T. Konstantinidis & Yong-Guan Zhu & Si-Yu Zhang, 2024. "Organic fertilization co-selects genetically linked antibiotic and metal(loid) resistance genes in global soil microbiome," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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