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Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor

Author

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  • Ming Hu

    (Huazhong University of Science and Technology)

  • Ying-Xue Yuan

    (Huazhong University of Science and Technology)

  • Weizhou Wang

    (Luoyang Normal University)

  • Dong-Mi Li

    (Luoyang Normal University)

  • Hong-Chao Zhang

    (Huazhong University of Science and Technology)

  • Bai-Xing Wu

    (Huazhong University of Science and Technology)

  • Minghua Liu

    (Chinese Academy of Sciences)

  • Yan-Song Zheng

    (Huazhong University of Science and Technology)

Abstract

Chiral recognition, such as enantioselective interactions of enzyme with chiral agents, is one of the most important issues in the natural world. But artificial chiral receptors are much less efficient than natural ones. For tackling the chiral recognition and enantiomer excess (ee) analysis, up until now all the fluorescent receptors have been developed based on fluorescence intensity changes. Here we report that the chiral recognition of a large number of chiral carboxylic acids, including chiral agrochemicals 2,4-D, is carried out based on fluorescent colour changes rather than intensity changes of AIEgen rotors. Moreover, the fluorescence wavelength of the AIEgen rotor linearly changes with ee of the carboxylic acid, enabling the ee to be accurately measured with average absolute errors (AAE) of less than 2.8%. Theoretical calculation demonstrates that the wavelength change is ascribed to the rotation of the AIEgen rotor upon interaction with different enantiomers.

Suggested Citation

  • Ming Hu & Ying-Xue Yuan & Weizhou Wang & Dong-Mi Li & Hong-Chao Zhang & Bai-Xing Wu & Minghua Liu & Yan-Song Zheng, 2020. "Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13955-z
    DOI: 10.1038/s41467-019-13955-z
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    Cited by:

    1. Song-Meng Wang & Yan-Fang Wang & Liping Huang & Li-Shuo Zheng & Hao Nian & Yu-Tao Zheng & Huan Yao & Wei Jiang & Xiaoping Wang & Liu-Pan Yang, 2023. "Chiral recognition of neutral guests by chiral naphthotubes with a bis-thiourea endo-functionalized cavity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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