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Image-guided neural activity manipulation with a paramagnetic drug

Author

Listed:
  • Sarah Bricault

    (Massachusetts Institute of Technology)

  • Ali Barandov

    (Massachusetts Institute of Technology)

  • Peter Harvey

    (Massachusetts Institute of Technology)

  • Elizabeth DeTienne

    (Massachusetts Institute of Technology)

  • Aviad Hai

    (Massachusetts Institute of Technology)

  • Alan Jasanoff

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

Abstract

Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.

Suggested Citation

  • Sarah Bricault & Ali Barandov & Peter Harvey & Elizabeth DeTienne & Aviad Hai & Alan Jasanoff, 2020. "Image-guided neural activity manipulation with a paramagnetic drug," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13933-5
    DOI: 10.1038/s41467-019-13933-5
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